930585-94-7

Basic information

• Product Name: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid
• Synonyms: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid
• CAS NO: 930585-94-7
• Molecular Weight: 291.39
• Mol File: 930585-94-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid(930585-94-7)
• EPA Substance Registry System: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid(930585-94-7)

Safety Data

• Hazardous Substances Data: 930585-94-7(Hazardous Substances Data)

Upstream product

• 75143-89-4 5-methyl-3-carboxymethylhexanoic acid 
• 185815-59-2 3-isobutylglutaric anhydride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 181289-33-8 (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid 
• 75143-89-4 5-methyl-3-carboxymethylhexanoic acid 

Relevant articles and documents

Asymmetrical synthesis method of lyrica

The invention discloses an asymmetrical synthesis method of lyrica, wherein the synthesis steps comprise: carrying out a cyclic anhydridization reaction by using 3-isobutylglutaric acid as a raw material, carrying out an asymmetric ring-opening reaction with (R)-(+)-1-phenylethylamine, and sequentially carrying out a hydrogenation reaction and Huffman rearrangement to obtain lyrica. Compared to the synthesis method in the prior art, the synthesis method of the present invention has advantages of inexpensive and easily-available raw materials and less reaction steps, has the total yield of up to 60%, the purity of the product lyrica of more than 99% and the ee value of more than 99%, and has good application prospect in industrial scale up production.