93134-37-3

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(4-oxopentanoate)
• CAS NO: 93134-37-3
• Molecular Formula: C36H38N2O9
• Molecular Weight: 642.706
• Mol File: 93134-37-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(4-oxopentanoate)(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(4-oxopentanoate)(93134-37-3)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(4-oxopentanoate)(93134-37-3)

Safety Data

• Hazardous Substances Data: 93134-37-3(Hazardous Substances Data)

Upstream product

• 123-76-2 levulinic acid 
• 40608-06-8 levulinic anhydride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 142554-09-4 5'-O-(4,4'-dimethoxytrityl)-3'-O-(5'-O-diisopropylsilylthymidyl)thymidine 
• 1393343-43-5 C₆₄H₈₇N₆O₁₅PSi 
• 1393343-42-4 1-{N₃-[5'-O-(4,4'-dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-thymidylyl]}-4-{N₃-[5'-O-(allyloxycarbonyl)-thymidylyl]}butane 
• 1393343-41-3 1-{N₃-[5'-O-(4,4'-dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-thymidylyl]}-4-{N₃-[5'-O-(allyloxycarbonyl)-3'-O-(levulinoyl)-thymidylyl]}butane 
• 87007-52-1 C₄₂H₄₇N₄O₁₄P 
• 82739-92-2 N⁶-Benzoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'5')-2'-deoxythymidine 
• 93134-53-3 C₄₆H₅₂N₇O₁₄P 
• 93134-45-3 C₄₇H₅₃N₄O₁₆P 
• 85532-80-5 C₄₈H₅₀N₅O₁₄P 
• 102147-72-8 C₅₈H₆₀N₄O₁₄Si 
• 102147-73-9 4-Oxo-pentanoic acid (2R,3S,5R)-2-{[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diphenyl-silanyloxymethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 102147-74-0 C₃₂H₃₆N₄O₁₀Si 

Relevant articles and documents

METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID

In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The

Preparation of N3-thymidine-butylene-N3-thymidine interstrand cross-linked DNA via an orthogonal deprotection strategy

A DNA duplex containing an N3-thymidine-butylene-N3-thymidine interstrand cross-link (ICL) was prepared using an on-column orthogonal deprotection strategy to permit different nucleotide sequence composition around the cross-linked site. The conditions us

Biodegradable protections for nucleoside 5′-monophosphates: Comparative study on the removal of O-acetyl and O-acetyloxymethyl protected 3-hydroxy-2,2-bis(ethoxycarbonyl)propyl groups

(Chemical Equation Presented) The applicability of 3-acetyloxy-2,2- bis(ethoxycarbonyl)propyl and 3-acetyloxymethoxy-2,2-bis(ethoxycarbonyl) propyl groups as biodegradable phosphate protecting groups for nucleoside 5′-monophosphates has been studied in a HEPES buffer at pH 7.5. Enzymatic deacetylation with porcine carboxyesterase triggers the removal of the resulting 3-hydroxy-2,2-bis(ethoxycarbonyl)propyl and 3-hydroxymethoxy-2,2- bis(ethoxycarbonyl)propyl groups by retro-aldol condensation and consecutive half acetal hydrolysis and retro-aldol condensation, respectively. The kinetics of these multistep deprotection reactions have been followed by HPLC, using appropriately protected thymidine 5′-monophosphates as model compounds. The enzymatic deacetylation of the 3-acetyloxymethoxy-2,2-bis(ethoxycarbonyl) propyl 5′-triester (2) is 25-fold faster than the deacetylation of its 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl-protected counterpart 1, and the difference in the deacetylation rates of the resulting diesters, 12b and 12a, is even greater. With 2, conversion to thymidine 5′-monophosphate (5′-TMP) is quantitative, while conversion of 1 to 5′-TMP is accompanied by formation of thymidine. Consistent with the preceding observations, quantitative release of 5′-TMP from 2 has been shown to take place in a whole cell extract of human prostate cancer cells.