93138-55-7

Basic information

• Product Name: 3-(PIPERIDIN-1-YLMETHYL)ANILINE
• Synonyms: AKOS MSC-0188;3-(PIPERIDIN-1-YLMETHYL)ANILINE;[3-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINE;3-(1-PIPERIDINYLMETHYL)ANILINE;CHEMBRDG-BB 4011235;3-(Piperidinylmethyl)aniline;3-(Piperidin-1-ylmethyl)aniline 97%;3-(Piperidylmethyl)phenylamine
• CAS NO: 93138-55-7
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Product Categories: Amines and Anilines;API intermediates
• Mol File: 93138-55-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 106 °C
• Boiling Point: 312.3 °C at 760 mmHg
• Flash Point: 128 °C
• Appearance: /
• Density: 1.068 g/cm³
• Vapor Pressure: 0.000533mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-(PIPERIDIN-1-YLMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(PIPERIDIN-1-YLMETHYL)ANILINE(93138-55-7)
• EPA Substance Registry System: 3-(PIPERIDIN-1-YLMETHYL)ANILINE(93138-55-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 93138-55-7(Hazardous Substances Data)

Usage

General Description

3-(Piperidin-1-ylmethyl)aniline is a chemical compound with the molecular formula C13H19N. It is a substituted aniline with a piperidine group attached to the amino moiety. 3-(PIPERIDIN-1-YLMETHYL)ANILINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a building block in the production of dyes, pigments, and other specialty chemicals. 3-(Piperidin-1-ylmethyl)aniline is typically handled and stored under strict laboratory conditions due to its potential hazards, and its use is regulated in many countries due to its potential health and environmental impacts.

InChI:InChI=1/C12H18N2/c13-12-6-4-5-11(9-12)10-14-7-2-1-3-8-14/h4-6,9H,1-3,7-8,10,13H2

Upstream product

• 110-89-4 piperidine 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 59507-46-9 3-(piperidin-1-ylmethyl)nitrobenzene 
• 77201-13-9 1-(3-amino-benzoyl)-piperidine 
• 99-61-6 3-nitro-benzaldehyde 
• 619-25-0 3-Nitrobenzyl alcohol 

Downstream Products

• 617709-34-9 N-[3-(Piperidinomethyl)phenyl]-3-[3-(3,5-dimethylbenzyl)-2-dicyanomethylidene imidazolidin-1-yl]propionamide 
• 617709-31-6 N-Isopropyl-3-(piperidinomethyl)aniline 
• 866955-76-2 ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-{[3-(piperidin-1-ylmethyl)phenyl]amino}acrylate 
• 866956-64-1 ethyl 3-{[3-(piperidin-1-ylmethyl)phenyl]amino}-2-[2,4,5-trifluoro-3-(trifluoromethoxy)benzoyl]acrylate 
• 503183-14-0 4-[(3-(piperidin-1-ylmethyl)phenyl)hydrazono]-4H-pyrazole-3,5-diamine 
• 1028338-73-9 1,4-dichloro-phthalazine-6-carboxylic acid (3-piperidin-1-ylmethyl-phenyl)-amide 
• 1185765-03-0 (4-piperidin-1-ylmethyl-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine 
• 73279-04-6 3-[1-piperidinylmethyl]phenol 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 78273-80-0 2-hydroxy-N-[3-[3-(piperidinomethyl)phenoxy]propyl] acetamide 
• 93793-83-0 Gastralgin 

Relevant articles and documents

Novel preparation method of intermediate namely 3-(1-piperidine methyl)phenol of roxatidine acetate hydrochloride

The invention relates to a preparation method of an intermediate namely 3-(1-piperidine methyl)phenol of roxatidine acetate hydrochloride. M-nitrobenzaldehyde is taken as the primary raw material; under the effect of a phase transfer catalyst, m- nitrobenzaldehyde is reduced by metal borohydride to obtain corresponding benzyl alcohol; in the presence of an alkali, benzyl alcohol reacts with organic sulfonyl chloride to generate active organic sulfonate; then in the presence of an alkali, organic sulfonate carries out N-alkylation reactions with piperidine to generate N-substituted piperidine derivatives; reducing the nitro groups of N-substituted piperidine derivatives to obtain corresponding amino compounds; and subjecting the amino compounds to diazotization, hydrolysis, and alkalizationin a sulfuric acid water solution to obtain 3-(1-piperidine methyl)phenol. The problem that the supply of the conventional raw material (m-hydroxyl benzaldehyde) is not enough and the cost is greatlyincreased is solved. The method is simple and safe, the raw materials are cheap and easily available, the reaction yield is high, and the method is very suitable for industrial production of 3-(1-piperidine methyl)phenol.

A convenient and general reduction of amides to amines with low-valent titanium

Low-valent titanium readily prepared in situ from TiCl4 and Mg powder in THF is found to be an active agent for the reduction of amides which were previously considered to be inert towards low-valent titanium. The reaction proceeds under very mild conditions, and is applicable to all types of amides, primary, secondary and tertiary, to produce the corresponding amines in good to excellent yields. This new finding provides a practical, convenient and general method for the important transformation of amides to amines. A plausible reaction mechanism is proposed.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.