93138-75-1

Basic information

• Product Name: N,N-diethyl-N'-(4-methylphenyl)urea
• Synonyms: N,N-diethyl-N'-(4-methylphenyl)urea
• CAS NO: 93138-75-1
• Molecular Weight: 206.288
• Mol File: 93138-75-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-N'-(4-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-N'-(4-methylphenyl)urea(93138-75-1)
• EPA Substance Registry System: N,N-diethyl-N'-(4-methylphenyl)urea(93138-75-1)

Safety Data

• Hazardous Substances Data: 93138-75-1(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 201230-82-2 carbon monoxide 
• 106-49-0 p-toluidine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 97600-24-3 3,3-diethyl-1-(4-tolyl)-1-nitrosourea 
• 19873-46-2 N-Methyl-N'-(4-tolyl)harnstoff 
• 622-58-2 p-Tolylisocyanate 
• 88-10-8 N,N-diethylcarbamyl chloride 

Downstream Products

• 15441-96-0 N,N-diethyl-N'-(2-chloro-4-methylphenyl)urea 
• 97600-24-3 3,3-diethyl-1-(4-tolyl)-1-nitrosourea 
• 105363-75-5 C₂₄H₃₄N₄O 

Relevant articles and documents

Visible-light-promoted oxidative desulphurisation: A strategy for the preparation of unsymmetrical ureas from isothiocyanates and amines using molecular oxygen

A green and efficient visible-light promoted oxidative desulphurisation protocol has been proposed for the construction of unsymmetrical ureas under mild conditions with broad substrate scope and good functional group tolerance. Most appealingly, the reaction can proceed smoothly without adding any strong oxidants. Control experiments and computational studies support a mechanism involving water-assisted in situ generation of thioureas and photocatalytic oxidative desulphurisation. The present method provides a promising synthesis strategy for the formation of diverse and useful unsymmetrical urea derivatives in the fields of pharmaceutical and synthetic chemistry.

Efficient Direct Halogenation of Unsymmetrical N -Benzyl- and N -Phenylureas with Trihaloisocyanuric Acids

A simple and efficient methodology for the direct halogenation of N -phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N -phenylureas with different patterns of substitution. Additionally, less reactive N -benzylureas were halogenated in the presence of a mixture of trifluoroacetic acid and acetonitrile at room temperature.

Carbonyldiimidazole-mediated lossen rearrangement

[Chemical Equation Presented] Carbonyldiimidazole (CDI) was found to mediate the Lossen rearrangement of various hydroxamic acids to isocyanates. This process is experimentally simple and mild, with imidazole and CO 2 being the sole stoichiometric byproduct. Significant for large-scale application, the method avoids the use of hazardous reagents and thus represents a green alternative to standard processing conditions for the Curtius and Hofmann rearrangements.