931395-73-2

Basic information

• Product Name: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid
• Synonyms: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid
• CAS NO: 931395-73-2
• Molecular Weight: 312.753
• Mol File: 931395-73-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 128～130℃
• CAS DataBase Reference: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid(931395-73-2)
• EPA Substance Registry System: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid(931395-73-2)

Safety Data

• Hazardous Substances Data: 931395-73-2(Hazardous Substances Data)

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 41667-95-2 5,6-dichloronicotinic acid 

Downstream Products

• 570406-98-3 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid 
• 570403-14-4 ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate 

Relevant articles and documents

Preparation method of thrombocyte increasing agent

The invention relates to a preparation method of a thrombocyte increasing agent. The preparation method comprises the following steps: enabling a midbody 1 and a midbody 2 to perform amidation in the presence of a catalyst in an aprotic solvent; and adding alkali into a solvent of a midbody A to perform the alkaline hydrolysis reaction to obtain a target compound. The midbody 2 is firstly synthesized and then reacts with the midbody 1; and a synthetic route of the method is a converging reaction, so that the yield is increased, and convenience in quality control is achieved. In addition, by studying the reaction amplification feasibility, the operation such as column chromatography is avoided, the method is more suitable for an industrialized production process, and the emission of waste liquid is reduced. A product obtained by the route is high in purity, the yield is high, the pollution is small, and the preparation method is suitable for the industrialized production.