932388-89-1

Basic information

• Product Name: 7-ChloroMethyl 17R-Drospirenone
• Synonyms: 7-ChloroMethyl 17R-Drospirenone;(7β,15α,16α)-7-(ChloroMethyl)-15,16-dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-4,15-diene-21-carboxylic Acid γ-Lactone;7β-(ChloroMethyl)-15β,16β-Methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone
• CAS NO: 932388-89-1
• Molecular Formula: C24H31ClO3
• Molecular Weight: 402.95414
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 932388-89-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 7-ChloroMethyl 17R-Drospirenone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-ChloroMethyl 17R-Drospirenone(932388-89-1)
• EPA Substance Registry System: 7-ChloroMethyl 17R-Drospirenone(932388-89-1)

Safety Data

• Hazardous Substances Data: 932388-89-1(Hazardous Substances Data)

Usage

Uses

7-Chloromethyl 17R-Drospirenone (Drospirenone EP Impurity H) is one of the two epimeric lactones from Drospirenone (D689500) acidic treatment. Drospirenone impurity.

Upstream product

• 90457-65-1 dihydrospirorenone 

Relevant articles and documents

Structure elucidation of new compounds from acidic treatment of the progestins gestodene and drospirenone

Gestodene acidic treatment afforded a single rearrangement product, namely 13-β-ethyl-18,19-dinorpregna-4,14,16-trien-3,20-dione 3, which was originated through HCl-catalyzed Rupe rearrangement. Drospirenone acidic treatment yielded two epimeric lactones by addition of HCl to the 6β,7β-cyclopropane ring, namely 7β-(chloromethyl)-15β,16β-methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone 4 and 7β-(chloromethyl)-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone 5. The structure of the compounds was assessed by spectroscopic and crystallographic methods.