93299-49-1Relevant articles and documents
A Concise Formal Total Synthesis of Mappicine and Nothapodytine B via an Intramolecular Hetero Diels-Alder Reaction
Toyota, Masahiro,Komori, Chiyo,Ihara, Masataka
, p. 7110 - 7113 (2000)
A six-step formal total synthesis of a natural alkaloid, mappicine (3), has been achieved. The highlight of our synthetic strategy is an intramolecular hetero Diels-Alder reaction that was used for the construction of the CD ring system of mappicine (3). In addition, it was demonstrated that the Sonogashira coupling reaction of 2-chloro-3-hydroxymethylquinoline (8c) with trimethylsilylacetylene proceeded at room temperature in excellent yield.
Synthesis of new 3-(2-Chloroquinolin-3-yl)-5-phenylisoxazole derivatives via click chemistry approach
Ferna?ndez-Galleguillos, Carlos,Saavedra, Luis A.,Gutierrez, Margarita
, p. 365 - 371 (2014/02/14)
Herein, we report the synthesis of new substituted 3-(2-chloroquinolin-3- yl)-5-phenylisoxazole (3a-j) by click chemistry in good to moderate yields. This approach is based on the regioselective copper(I)-catalyzed cycloaddition between different nitrile oxides derived from 2-chloroquinoline- 3-carbaldehyde (2a-j) and phenylacetylene. Finally these derivatives were screened for their antibacterial evaluation in vitro against three Gram-negative clinical bacteria: Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii using standard methods.
Synthesis of novel pyrazoloquinolines
Praveen Kumar Darsi,Shiva Kumar,Rama Devi,Naidu,Dubey
, p. 237 - 244 (2013/09/24)
The synthesis of novel pyrazoloquinolines, 3-(1H-pyrazolo [3,4-6] quinolin-3-ylimino) indolin-2-one (5) and 1-methyl-3-(1-methyl-1H-pyrazolo [3,4-b] quinolin-3-ylimino)-1,3-dihydro-indol-2-one (6) is described. Reaction of 2-chloroquinolin-3-carboxaldehyd