93324-84-6Relevant articles and documents
Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones
Agrawal, Neetu,Upadhyay, Prabhat K.,Mujwar, Somdutt,Mishra, Pradeep
, p. 39 - 46 (2020/03/19)
A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones (T
Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel: S -triazine derivatives
Shanmugam, Mani,Narayanan, Kuppusamy,Hari Prasad, Kamatam,Karthikeyan, Dhanapalan,Chandrasekaran, Loganathan,Atchudan, Raji,Chidambaranathan
, p. 1698 - 1714 (2018/02/09)
In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using an s-triazine scaffold, via amine and Schiff base derivatives, has been developed. In order to obtain antitumor activity, all synthesized compounds were screened in vitro for their cytotoxicity against human fibrosarcoma tumor cells (HT-1080) and a cervical cancer cell line (HeLa), for their ability to inhibit the growth of cancer cells. The selected s-triazine analogs (5c, 5d, and 6c) have been preliminarily studied for their reactive oxygen species (ROS) properties, mitochondrial membrane potential (MMP) and apoptosis (AO/EtBr) activity against the HT-1080 cancer cell line. The in vitro anticancer activity analysis has revealed that the synthesized compounds have good/moderate inhibitory activity against the tested cell lines compared to the standard drug. The theoretical study results also provide evidence that the s-triazines scaffolds have been successfully identified as superior p53-MDM2 inhibitors through structure-based design.
A thermal study of some Schiff bases derivative of α-napthylamine
Baluja, Shipra,Pandya, Nirmal,Vekariya, Nayan
experimental part, p. 1601 - 1604 (2009/02/03)
Thermal analyses of some Schiff bases, derivative of α-napthylamine, were performed by the DSC, TG and DTA techniques. The thermograms were used to determine various kinetic parameters, such as the order of degradation (n), energy of activation (E), frequ