93351-38-3

Basic information

• Product Name: 3-BUTOXY-BENZOIC ACID
• Synonyms: AKOS BBB/283;AKOS B000081;3-BUTOXY-BENZOIC ACID;ARONIS010179;BAS 00705319;MLS000077181;SMR000009460;ST5238360
• CAS NO: 93351-38-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol File: 93351-38-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• PKA: pK1: 4.25 (20°C)
• CAS DataBase Reference: 3-BUTOXY-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BUTOXY-BENZOIC ACID(93351-38-3)
• EPA Substance Registry System: 3-BUTOXY-BENZOIC ACID(93351-38-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 93351-38-3(Hazardous Substances Data)

Upstream product

• 178552-51-7 3-butoxy-benzoic acid ethyl ester 
• 109-65-9 1-bromo-butane 
• 99-06-9 3-Carboxyphenol 
• 7781-98-8 ethyl-3-hydroxybenzoate 
• 585-76-2 m-bromobenzoic acid 
• 71-36-3 butan-1-ol 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 152091-60-6 methyl 3-n-butoxybenzoate 

Downstream Products

• 89790-29-4 m-(n-butoxy)benzoyl chloride 

Relevant articles and documents

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their selective fusion with lysosomes. In this study, we show that the homologous members of the human Atg8 family proteins, LC3A and LC3B, are druggable by a small molecule inhibitor novobiocin. Structure-activity relationship (SAR) studies of the 4-hydroxy coumarin core scaffold were performed, supported by a crystal structure of the LC3A dihydronovobiocin complex. The study reports the first nonpeptide inhibitors for these protein interaction targets and will lay the foundation for the development of more potent chemical probes for the Atg8 protein family which may also find applications for the development of autophagy-mediated degraders (AUTACs).

Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcohols and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature. Additionally, a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

ALLYLQXY AND ALKYLOXY BENZOIC ACID DELIVERY AGENTS

The present invention relates to pharmaceutical compounds for delivering active agents, such as biologically or chemically active agents, to a target. The invention also relates to pharmaceutical compositions comprising at least one delivery agent compound of the present invention and at least one active agent, and unit dosage forms comprising such compositions. Methods for the preparation and administration of the pharmaceutical compositions are also disclosed.