93503-09-4 Usage
Description
(S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is a chiral chemical compound belonging to the aminotetraline class. It is the hydrochloride salt of 7-methoxy-N-propyl-2-aminotetraline, a derivative of tetraline. (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is characterized by its (S)-enantiomer being the active form, while the (-)-enantiomer is inactive. With potential applications in the pharmaceutical and medical fields, it is known for its psychoactive and pharmacological properties. Due to its potent effects on the central nervous system and possible interactions with other substances, caution is advised in handling and using this compound.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is used as a psychoactive compound for its potential role in the development of medications targeting the central nervous system. Its pharmacological properties make it a candidate for further research and development in the creation of new drugs.
Used in Medical Research:
In the field of medical research, (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is used as a research tool to study the effects of chiral molecules on the central nervous system. This can contribute to a better understanding of the molecular mechanisms underlying various neurological and psychiatric disorders, potentially leading to the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 93503-09-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,5,0 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 93503-09:
(7*9)+(6*3)+(5*5)+(4*0)+(3*3)+(2*0)+(1*9)=124
124 % 10 = 4
So 93503-09-4 is a valid CAS Registry Number.
93503-09-4Relevant articles and documents
Further delineation of hydrophobic binding sites in dopamine D 2/D3 receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6,7,8-tetrahydro-naphthalen-2-ol
Ghosh, Balaram,Antonio, Tamara,Gopishetty, Bhaskar,Reith, Maarten,Dutta, Aloke
experimental part, p. 5661 - 5674 (2010/10/01)
Here we report a structure-activity relationship (SAR) study of analogues of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol. Our SAR is focused on introduction of various substitutions in the piperazine ring of the hybrid template. The goal behind this study is to delineate the nature of the binding pocket for N-aryl substitution in the piperazine ring by observing the effect of various hydrophobic and other heteroaromatic substitutions on binding affinity (Ki), as measured with tritiated spiperone and HEK-293 cells expressing either D2 or D3 receptors. Functional activity of selected compounds was assessed with the GTPγS binding assay. Compound 8d was the most selective for the D3 receptor in the spiperone binding assay. An interesting similarity in binding affinity was observed between isoquinoline derivative D-301 and the 2-substituted pyridine derivative 8d, suggesting the importance of relative spatial relationships between the N-atom of the ligand and the molecular determinants of the binding pocket in D2/D3 receptors. Functional activity assays demonstrated high potency and selectivity of (+)-8a and (-)-28b (D2/D3 (ratio of EC50): 105 and 202, respectively) for the D3 receptor and both compounds were more selective compared to the reference drug ropinirole (D2/D3 (ratio of EC50): 29.5).
