93552-75-1

Basic information

• Product Name: Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, phenylmethyl ester
• CAS NO: 93552-75-1
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.294
• Mol File: 93552-75-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, phenylmethyl ester(93552-75-1)
• EPA Substance Registry System: Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, phenylmethyl ester(93552-75-1)

Safety Data

• Hazardous Substances Data: 93552-75-1(Hazardous Substances Data)

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 93552-78-4 benzyl 2,3-dioxobutanoate 
• 101184-50-3 benzyl 5-cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 200805-97-6 3-Oxo-2-[1-(4-oxo-4H-pyrido[1,2-a]pyrimidin-3-ylamino)-meth-(E)-ylidene]-butyric acid benzyl ester 
• 200806-00-4 2-[1-(8-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-ylamino)-meth-(E)-ylidene]-3-oxo-butyric acid benzyl ester 
• 200806-07-1 2-[1-(7-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-ylamino)-meth-(E)-ylidene]-3-oxo-butyric acid benzyl ester 

Relevant articles and documents

Synthesis and reactions of reduced flavones

The cycloadditions of a series of 4H-pyran-4-ones 3c-e with electron-rich dienes 11a,b to give reduced flavones 12 is described. The subsequent reactions of these reduced flavones with HCl, trifluoroacetic anhydride, ethyl anthranilate 19a and anthranilon

NEW PYRIDINE ANALOGUES

The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

Inotropic agents. Synthesis and structure-activity relationships of new milrinone related cAMP PDE III inhibitors

The synthesis of 6-substituted 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles 1b,c, 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarbonitriles 1d-g and esters of 5-cyano-1,6-dihydro-2-methyl-6-oxo-3-pyridinecarboxylic acid 2b-e is described. In the case of le and If, a careful elucidation of the reaction mechanism is discussed. As milrinone analogues, the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria from reserpine-treated guinea pigs. The methyl and tile benzyl esters 2b and 2e showed an appreciable positive inotropic activity when compared to milrinone. A fitting study with the DISCO (Distance Comparison) model has been carried out on 2e. This modeling approach allowed for the improvement of the pharmacophoric requirements for a better interaction with the cAMP-specific PDE (PDE III), thought to be the final biological target of these cardiotonic agents.