935520-39-1

Basic information

• Product Name: 2-(4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile
• Synonyms: 2-(4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile
• CAS NO: 935520-39-1
• Molecular Weight: 266.198
• Mol File: 935520-39-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile(935520-39-1)
• EPA Substance Registry System: 2-(4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile(935520-39-1)

Safety Data

• Hazardous Substances Data: 935520-39-1(Hazardous Substances Data)

Upstream product

• 732306-64-8 bis(4-fluorophenyl)iodonium triflate 
• 216431-85-5 6-(trifluoromethyl)nicotinonitrile 
• 386704-06-9 2-chloro-6-(trifluoromethyl)nicotinonitrile 
• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts

Arylation, vinylation, and alkynylation of electron-deficient arenes and heteroarenes have been achieved by chemoselective C-H zincation followed by copper-catalyzed coupling reactions using iodonium salts. This approach offers a direct and general access to a wide scope of (hetero)biaryls as well as alkenylated and alkynylated heteroarenes under mild conditions. It is particularly useful and valuable for the rapid and modular synthesis of diverse (hetero)aryl compounds, as demonstrated in the synthesis of transient receptor potential vanilloid 1 (TRPV1) antagonists and angiotensin II receptor type 1 (AT1 receptor) antagonists.

NOVEL VANILLOID RECEPTOR LIGANDS AND USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS

The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.