935528-07-7

Basic information

• Product Name: (4-ethynylphenyl)methanamine monohydrochloride
• CAS NO: 935528-07-7
• Molecular Weight: 167.638
• Mol File: 935528-07-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-ethynylphenyl)methanamine monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-ethynylphenyl)methanamine monohydrochloride(935528-07-7)
• EPA Substance Registry System: (4-ethynylphenyl)methanamine monohydrochloride(935528-07-7)

Safety Data

• Hazardous Substances Data: 935528-07-7(Hazardous Substances Data)

Usage

Description

(4-ethynylphenyl)methanamine monohydrochloride, also known as 4-ethynylphenylmethanamine hydrochloride, is a crystalline compound with the molecular formula C9H9N.HCl. It is a derivative of phenylmethanamine and contains an ethynyl group. (4-ethynylphenyl)methanamine monohydrochloride has potential applications in medicinal and pharmaceutical research, as well as in organic chemistry. It is important to handle and use this compound with caution, as it is a highly potent chemical and should be handled in accordance with proper safety guidelines and regulations.

Uses

Used in Medicinal and Pharmaceutical Research:
(4-ethynylphenyl)methanamine monohydrochloride is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the ethynyl group, allows for the development of new drugs with potential therapeutic applications.
Used in Organic Chemistry:
(4-ethynylphenyl)methanamine monohydrochloride is used as a reagent or building block in organic synthesis. Its ethynyl group can be utilized in various chemical reactions, enabling the creation of a wide range of organic compounds for research and industrial purposes.
Used in Chemical Intermediates:
(4-ethynylphenyl)methanamine monohydrochloride is used as a key intermediate in the production of other chemical compounds. Its versatility and reactivity make it a valuable component in the synthesis of various specialty chemicals and materials.
Used in Research and Development:
(4-ethynylphenyl)methanamine monohydrochloride is used in research and development laboratories to explore its properties and potential applications. Its unique structure and reactivity make it an interesting subject for scientific investigation and the development of new technologies.

Upstream product

• 3032-92-6 4-cyanophenylacetylene 
• 1097834-15-5 1-(azidomethyl)-4-ethynylbenzene 
• 680190-95-8 (4-trimethylsilylethyn-1-ylbenzyl)carbamic acid tert-butyl ester 
• 68819-84-1 tert-butyl N-(4-bromobenzyl)carbamate 

Relevant articles and documents

Selective Acceptorless Dehydrogenation of Primary Amines to Imines by Core–Shell Cobalt Nanoparticles

Core–shell nanocatalysts are attractive due to their versatility and stability. Here, we describe cobalt nanoparticles encapsulated within graphitic shells prepared via the pyrolysis of a cationic poly-ionic liquid (PIL) with a cobalt(II) chloride anion. The resulting material has a core–shell structure that displays excellent activity and selectivity in the self-dehydrogenation and hetero-dehydrogenation of primary amines to their corresponding imines. Furthermore, the catalyst exhibits excellent activity in the synthesis of secondary imines from substrates with various reducible functional groups (C=C, C≡C and C≡N) and amino acid derivatives.

Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines

Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands

Novel N-substituted indol-3-ylglyoxylamides (10-37) were synthesized and evaluated as ligands of the benzodiazepine receptor (BzR). In an effort to achieve affinity-based selectivity among BzR subtypes, these compounds were designed to probe the LDi