935687-49-3

Basic information

• Product Name: Benzyl 6-aminonicotinate
• Synonyms: Benzyl 6-aminonicotinate;Benzyl 6-aminopyridine-3-carboxylate;2-Amino-5-(benzyloxycarbonyl)pyridine;6-Aminonicotinic acid benzyl ester
• CAS NO: 935687-49-3
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.24658
• EINECS: -0
• Mol File: 935687-49-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 420.461°C at 760 mmHg
• Flash Point: 208.088°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Benzyl 6-aminonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 6-aminonicotinate(935687-49-3)
• EPA Substance Registry System: Benzyl 6-aminonicotinate(935687-49-3)

Safety Data

• Hazardous Substances Data: 935687-49-3(Hazardous Substances Data)

Usage

General Description

Benzyl 6-aminonicotinate is a chemical compound with the molecular formula C14H13N3O2. It is a derivative of nicotinic acid and contains a benzyl group and an amino group attached to the sixth carbon of the nicotinate ring. Benzyl 6-aminonicotinate is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals. It has demonstrated potential as an anti-inflammatory and analgesic agent in preclinical studies. Benzyl 6-aminonicotinate may also have applications in the treatment of neurological disorders and as a building block for the development of new therapeutic compounds. Overall, this chemical is of interest for its potential pharmacological properties and its role as a starting material for the synthesis of bioactive molecules.

InChI:InChI=1/C13H12N2O2/c14-12-7-6-11(8-15-12)13(16)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,14,15)

Upstream product

• 3167-49-5 6-aminonicotinic acid 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 1072-97-5 5-bromo-2-pyridylamine 
• 124-38-9 carbon dioxide 

Downstream Products

• 1215198-26-7 (S)-benzyl 6-(3-cyclopentyl-2-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinate 
• 1215198-50-7 (S)-benzyl 6-(3-cyclopentyl-2-(4-(ethylsulfonyl)-1H-imidazol-1-yl)propanamido)nicotinate 
• 1215197-09-3 (S)-benzyl 6-(3-cyclopentyl-2-(4-(methylsulfonyl)-1H-pyrazol-1-yl)propanamido)nicotinate 
• 1215197-25-3 (S)-benzyl 6-(3-cyclopentyl-2-(4-(methylsulfonyl)-1H-imidazol-1-yl)propanamido)nicotinate 
• 1215197-82-2 (S)-benzyl 6-(3-cyclopentyl-2-(3-(trifluoromethyl)-1H-1,2,4-triazol-1yl)propanamido)nicotinate 
• 1215197-90-2 (S)-benzyl 6-(3-cyclopentyl-2-(4-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propanamido)nicotinate 
• 1215198-24-5 (S)-benzyl 6-(3-cyclohexyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinate 
• 1235443-33-0 (S)-benzyl 6-(2-(2-oxo-5-(trifluoromethyl)pyrazin-1(2H)-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamido)nicotinate 
• 1235443-35-2 (S)-benzyl 6-(3-cyclopentyl-2-(2-oxo-5-(trifluoromethyl)pyrazin-1(2H)-yl)propanamido)nicotinate 
• 1235443-45-4 (S)-benzyl 6-(3-cyclobutyl-2-(2-oxo-5-(trifluoromethyl)pyrazin-1(2H)-yl)propanamido)nicotinate 
• 3167-49-5 6-aminonicotinic acid 
• 1314003-60-5 C₁₄H₁₀N₂O₃ 
• 1314003-59-2 meptazinol 6-aminonicotinic acid carbamate benzyl ester 
• 1314003-61-6 meptazinol 6-aminonicotinic acid carbamate 

Relevant articles and documents

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl) propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus

Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. Systemically acting glucokinase activators (liver and pancreas) have bee

Electrocatalytic carboxylation of 2-amino-5-bromopyridine with CO 2 in ionic liquid 1-butyl-3-methyllimidazoliumtetrafluoborate to 6-aminonicotinic acid

A new electrochemical procedure for the electrocatalytic carboxylation of 2-amino-5-bromopyridine with CO2 in ionic liquid, 1-butyl-3-methyllimidazolium tetrafluoborate (BMIMBF4), to 6-aminonicotinic acid was investigated for the first time. The experiments were carried out in three electrodes undivided cell under mild conditions, and the use of volatile and toxic solvents and catalysts, as well as any other additional supporting electrolytes, was avoided. The electrochemical reduction behavior of 2-amino-5-bromopyridine in BMIMBF4 had been studied by cyclic voltammetry with a reduction peak at-1.6V (vs. Ag). 6-Aminonicotinic acid was obtained in 75% yield and 100% selectivity, under the optimized condition. Moreover, the ionic liquid was successfully recycled.

HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS

The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.