935846-41-6

Basic information

• Product Name: ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate
• Synonyms: ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate
• CAS NO: 935846-41-6
• Molecular Weight: 480.358
• Mol File: 935846-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate(935846-41-6)
• EPA Substance Registry System: ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate(935846-41-6)

Safety Data

• Hazardous Substances Data: 935846-41-6(Hazardous Substances Data)

Upstream product

• 637301-05-4 4-methoxybenzyl 2’-iodophenyl ether 
• 824-94-2 p-methoxybenzyl chloride 
• 16732-69-7 ethyl 7-bromo-1H-indole-2-carboxylate 
• 533-58-4 2-Iodophenol 
• 935846-38-1 ethyl 7-bromo-3-iodoindole-2-carboxylate 
• 935846-39-2 2-(2-((4-methoxybenzyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 935846-43-8 ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 
• 935846-46-1 ethyl 1-allyloxycarbonyl-7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 

Relevant articles and documents

Oxidative rearrangement of Indoles: A new approach to the EFHG-tetracyclic core of diazonamide A

(Chemical Equation Presented) A new approach to the ring EFHG-tetracyclic core fragment of the marine secondary metabolite diazonamide A is described. The route is based on the oxidative rearrangement of 3-arylindole-2-carboxylates. Thus, a range of 3-arylindole-2-carboxylates (3, 8) underwent rearrangement to the corresponding 3,3-disubstituted oxindoles (4, 9) with migration of the ester group upon treatment with tert-butyl hypochlorite followed by acid. The oxindoles 9 with a 3-[2-(4-methoxybenzyloxy)]phenyl substituent underwent cyclization to the tetracyclic aminals 11 following N-protection, reduction, and treatment with methanesulfonic anhydride. The methodology was applied to the tyrosine-indole derivative 17 to give the EFHG-tetracyclic core of diazonamide A.