936847-40-4Relevant articles and documents
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins
Tang, Guozhi,Yang, Chao-Yie,Nikolovska-Coleska, Zaneta,Guo, Jie,Qiu, Su,Wang, Renxiao,Gao, Wei,Wang, Guoping,Stuckey, Jeanne,Krajewski, Krzysztof,Jiang, Sheng,Roller, Peter P.,Wang, Shaomeng
, p. 1723 - 1726 (2007/10/03)
We report herein a new class of small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound, 7, binds to Bcl-2, Bcl-xL, and Mcl-1 proteins with Ki of 110, 638, and 150 nM, respectively. Compound 7 is highly effective in