93711-85-4 Usage
Description
(3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(RS)-1-(hydroxycarbonyl)ethyl]-2-azetidinone is a complex organic compound derived from azetidinone, featuring a unique molecular structure with specific stereochemistry and functional groups. The presence of (R)-1-(tert-butyldimethylsilyloxy)ethyl and (RS)-1-(hydroxycarbonyl)ethyl groups endows the molecule with distinct properties, making it a promising candidate for applications in organic synthesis and medicinal chemistry.
Uses
Used in Organic Synthesis:
(3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(RS)-1-(hydroxycarbonyl)ethyl]-2-azetidinone is used as a building block for the synthesis of more complex organic molecules, taking advantage of its unique molecular structure and functional groups to create a diverse range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(RS)-1-(hydroxycarbonyl)ethyl]-2-azetidinone is used as a potential drug candidate due to its specific properties and interactions with biological systems. The stereochemistry of the compound, particularly the (3S,4S) configuration, is crucial for its effectiveness and selectivity in targeting specific biological pathways.
Used in Pharmaceutical Industry:
(3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(RS)-1-(hydroxycarbonyl)ethyl]-2-azetidinone is used as an intermediate in the development of new pharmaceuticals, leveraging its unique structural features to design and synthesize novel therapeutic agents with improved efficacy and selectivity.
Used in Research and Development:
(3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(RS)-1-(hydroxycarbonyl)ethyl]-2-azetidinone is also utilized in research and development settings to study its properties, reactivity, and potential applications in various chemical and biological processes. Understanding its behavior can lead to the discovery of new reactions and the development of innovative synthetic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 93711-85-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,7,1 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 93711-85:
(7*9)+(6*3)+(5*7)+(4*1)+(3*1)+(2*8)+(1*5)=144
144 % 10 = 4
So 93711-85-4 is a valid CAS Registry Number.
93711-85-4Relevant articles and documents
Preparation method of meropenem intermediate 4-BMA
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Paragraph 0085; 0086; 0087; 0088; 0089; 0090; 0091-0123, (2017/03/18)
The invention provides a preparation method of a meropenem intermediate 4-BMA. Low-reaction-activity propionyl spirobenzoxazine cyclohexane is adopted, the meropenem intermediate 4-BMA is prepared through Reformatsky reaction and hydrolysis reaction in sequence, and in the preparation process, side reactions participating in reaction are few, further obtained product impurities are less, and the prepared 4-BMA is high in purity. In addition, the propionyl spirobenzoxazine cyclohexane is adopted as a raw material, the reaction yield is not affected, on the contrary, the reaction yield is greatly improved, and high reaction yield is obtained. Further, the adopted synthetic process is simple, post-treatment is convenient and easy to operate, the raw material and a catalyst are cheap and easy to obtain, safe and environmentally friendly, and the preparation cost is low. An experimental result shows that the mole yield of the prepared meropenem intermediate 4-BMA is 90.0% or above, and the purity is 98.5% or above.
1,3 IMIDAZOLIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF CARBAPENEM
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Page/Page column 6, (2011/02/18)
Preparation of new heterocyclic compounds characterised by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1β-methylcarbapenem production
Method for manufacturing stereoselective preparation of 4-bma using a chiral auxiliary and chiral auxiliary
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Page/Page column 5; 9, (2011/08/04)
The present invention relates to a process for preparing (3R,4S)-3-[[[R]-1 ' -t-butyldimethylsilyloxy ]ethyl]-4-[(R)-1 "-carboxyethyl]-2-azetidinone (beta- methylazetidin-2-one; 4-BMA), a key intermediate for the synthesis of carbapenem and penem antibiotics. Specifically, the present invention relates to a process comprising first, the preparation of a chiral auxiliary from cheap L-Phenylalaninol, and then the preparation of 4-BMA in high yield and high selectivity, under industrially mild condition.
