939-69-5Relevant articles and documents
An allylated firefly luciferin analogue with luciferase specific response in living cells
Ikeda, Yuma,Saitoh, Tsuyoshi,Niwa, Kazuki,Nakajima, Takahiro,Kitada, Nobuo,Maki, Shojiro A.,Sato, Moritoshi,Citterio, Daniel,Nishiyama, Shigeru,Suzuki, Koji
, p. 1774 - 1777 (2018)
An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).
Reduction Triggered in Situ Polymerization in Living Mice
Chen, Zixin,Cui, Lina,Fréchet, Jean M. J.,Gambhir, Sanjiv S.,Kierstead, Paul H.,Kothapalli, Sri-Rajasekhar,Liu, Jun,Ma, Xiaowei,Rao, Jianghong,Smith, Bryan Ronain,Taylor, Madelynn,Vivona, Sandro
supporting information, p. 15575 - 15584 (2020/10/18)
"Smart"biomaterials that are responsive to physiological or biochemical stimuli have found many biomedical applications for tissue engineering, therapeutics, and molecular imaging. In this work, we describe in situ polymerization of activatable biorthogonal small molecules in response to a reducing environment change in vivo. We designed a carbohydrate linker- and cyanobenzothiazole-cysteine condensation reaction-based small molecule scaffold that can undergo rapid condensation reaction upon physiochemical changes (such as a reducing environment) to form polymers (pseudopolysaccharide). The fluorescent and photoacoustic properties of a fluorophore-tagged condensation scaffold before and after the transformation have been examined with a dual-modality optical imaging method. These results confirmed the in situ polymerization of this probe after both local and systemic administration in living mice.
DERIVATIVES OF LUCIFERIN AND METHODS FOR THEIR SYNTHESIS
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Page/Page column 27, (2019/02/13)
6-Thio derivatives of D-luciferin, also referred to as D-thioluciferins, having the general structure of Formula (I) are provided. Methods for synthesising D-luciferin, its derivatives, and their related 2-cyanobenzothiazole precursors are also provided. These compounds are commercially valuable due to their application in optical imaging, particularly in bioluminescence imaging.