94001-64-6

Basic information

• Product Name: 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL
• Synonyms: 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL
• CAS NO: 94001-64-6
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• EINECS: -0
• Mol File: 94001-64-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 366.6 °C at 760 mmHg
• Flash Point: 161.3 °C
• Appearance: /
• Density: 1.099 g/cm³
• CAS DataBase Reference: 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL(94001-64-6)
• EPA Substance Registry System: 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL(94001-64-6)

Safety Data

• Hazardous Substances Data: 94001-64-6(Hazardous Substances Data)

Usage

General Description

3,5-Bis(chloromethyl)pyridine HCL is a chemical compound that contains two chloromethyl groups attached to a pyridine ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has potential applications in the development of novel materials and in chemical research. 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL is highly reactive and should be handled with care due to its potential to cause irritation to the skin, eyes, and respiratory system. It is important to follow safety precautions and proper handling procedures when working with 3,5-Bis(chloromethyl)pyridine HCL to minimize the risk of exposure and adverse health effects.

InChI:InChI=1/C7H7Cl2N.ClH/c8-2-6-1-7(3-9)5-10-4-6;/h1,4-5H,2-3H2;1H

Upstream product

• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 917-54-4 methyllithium 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 

Downstream Products

• 34564-79-9 1-methoxy-3-(1-phenylvinyl)benzene 

Relevant articles and documents

Distinctive meta-directing group effect for iridium-catalyzed 1,1-diarylalkene enantioselective hydrogenation

An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3

Electron Transfer in Reactions of Ketones with Organolithium Reagents. A Carbon-14 Kinetic Isotope Effect Probe

Kinetic isotope effects have been determined for reactions of ketones labeled with carbon-14 at the carbonyl carbon with MeLi and Me2CuLi in diethyl ether at 0 deg C.Observed isotope effects were as follows: (C6H5)2C=O + MeLi, 12k/14k = 1.000 +/- 0.002; (C6H5)2C=O + Me2CuLi, 1.029 +/- 0.005; 2,4,6-Me3C6H2COC6H5 + MeLi, 1.023 +/- 0.004.The relative reactivities of ortho-, meta-, and para-substituted benzophenones with these reagents were also determined by the competition experiments.These results are consistent with an electron transfer step which is followed by a carbon-carbon bond-formimg step that is or is not rate determining depending on the structure of ketones and reagents.The reaction of benzophenone with MeLi proceeds via rate-determining electron transfer; the change in nucleophile from MeLi to Me2CuLi shifts the rate-determining step from electron-transfer to recombination; the change in ketone from benzophenone to 2,4,6-trimethylbenzophenone also shifts the rate-determining step from electron transfer to recombination because the latter step becomes slower for the more hindered ketone.The extent of the geometrical change of the substrate at the electron-transfer transition state of the reaction of benzophenone with MeLi was estimated to be small on the basis of the magnitude of the KIE and teh ρ value of the Hammett correlation.