942-91-6Relevant articles and documents
Interconvertible living radical and cationic polymerization through reversible activation of dormant species with dual activity
Aoshima, Hiroshi,Uchiyama, Mineto,Satoh, Kotaro,Kamigaito, Masami
, p. 10932 - 10936 (2014)
The polymerization of vinyl monomers generally requires the selection of an appropriate single intermediate whereas in copolymerization the selection of the comonomer is limited by the intermediate. Herein we propose interconvertible dual active species that can connect comonomers through different mechanisms to produce specific comonomer sequences in a single polymer chain. More specifically two different stimuli that is a radical initiator and a Lewis acid are used to activate the common dormant CSC(S)Z group into radical and cationic species thereby inducing interconvertible radical and cationic copolymerization of acrylate and vinyl ether to produce a copolymer chain that consists of radically and cationically polymerized segments. The dual reversible activation provides control over molecular weights and multiblock copolymers with tunable segment lengths.
An efficient one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazoles from aldehydes and hydrazides using Lawesson’s reagent
Ko, Inseok,Park, Soojin,Lee, Goeun,Kim, Hakwon
, p. 67 - 78 (2019/03/07)
Five-membered heterocyclic-ring systems, such as thiadiazoles, remain an important and prevalent scaffold in the development of novel leads in medicinal chemistry for a variety of therapeutic targets. A two-step, one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from aryl hydrazides and aryl aldehydes using Lawesson’s reagent is described, yielding 2,5-disubstituted-1,3,4-thiadiazoles in moderate-to-high yields. Based on preliminary biological experiments, some of the newly synthesized thiadiazoles show antioxidant activity.
Synthesis and biological evaluation of 5′-phenyl-3′H-spiro- [indoline-3,2′-[1,3,4]oxadiazol]-2-one analogs
Liu, Hua-Quan,Wang, De-Cai,Wu, Fei,Tang, Wei,Ouyang, Ping-Kai
, p. 929 - 933 (2013/09/24)
A series of 5′-phenyl-3′H-spiro[indoline-3,2′-[1,3,4] thiadiazol]-2-one analogs were synthesized and their Bcl-2 protein inhibitory activities were studied. The lead compound was originally identified using a fluorescence polarization-based competitive binding assay. Among the 10 compounds investigated, 1k showed good binding affinities to Bcl-xL and Mcl-1, with inhibition constants of 8.9 μmol/L and 3.4 μmol/L, respectively. While compound 1c achieved tight binding affinities to Bcl-xL (Ki = 0.16 μmol/L), has the potential to be a new lead compound.
