94224-92-7

Basic information

• Product Name: methyl 4-(iodomethyl)benzoate
• Synonyms: methyl 4-(iodomethyl)benzoate
• CAS NO: 94224-92-7
• Molecular Weight: 276.074
• Mol File: 94224-92-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: methyl 4-(iodomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(iodomethyl)benzoate(94224-92-7)
• EPA Substance Registry System: methyl 4-(iodomethyl)benzoate(94224-92-7)

Safety Data

• Hazardous Substances Data: 94224-92-7(Hazardous Substances Data)

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 619-66-9 4-Carboxybenzaldehyde 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 1571-08-0 methyl 4-formylbenzoate 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 1642-81-5 p-(chloromethyl)benzoic acid 

Downstream Products

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 797-21-7 1,2-bis(4-methoxycarbonylphenyl)ethane 
• 1422039-03-9 methyl 4-(2,2-difluoro-2-iodoethyl)-benzoate 
• 58334-93-3 4-(2-hydroxyethoxymethyl)benzoic acid methyl ester 
• 1302579-68-5 C₂₀H₂₇NO₅ 
• 23450-30-8 methyl 4-benzylbenzoate 

Relevant articles and documents

RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS

Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof, which comprises the following steps: in a protective atmosphere, carrying out heating reaction on aryl aldehyde and iodine elementary substance in the presence of a solvent and phosphorous acid to obtain benzyl iodide and derivatives thereof. According to the method, cheap and green solid phosphorous acid is selected as a reduction reagent for reaction, elemental iodine is selected as an iodine source, the benzyl iodide and the derivatives thereof are efficiently prepared from the aryl aldehyde compounds which are simple and easy to obtain by a one-pot one-step method under mild conditions, and the method has the advantages of simplicity in operation, cheap and easily available reagents, environmental friendliness and the like; and the use of expensive silicon-hydrogen compounds and transition metal catalysts is avoided, and the yield can reach 94% at most, so that the method is beneficial to industrial production.

Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties

Indoleamine 2,3-dioxygenase 1 (IDO1)-mediated kynurenine pathway of tryptophan degradation is identified as an important immune effector pathway in the tumor cells to escape a potentially effective immune response. IDO1 is an attractive target for anticancer therapy and the discovery of IDO1 inhibitors has been intensely ongoing in both academic research laboratories and pharmaceutical organizations. Our study discovered that 1H-indazole was a novel key pharmacophore with potent IDO1 inhibitory activity. A series of new 1H-indazole derivatives were synthesized and determined the enzyme inhibitory activities, and the compound 2g exhibited the highest activity with an IC50value of 5.3 μM. The structure–activity relationships (SARs) analysis of the 1H-indazole derivatives as novel IDO1 inhibitors indicated that the 1H-indazole scaffold is necessary for IDO1 inhibition, and the substituent groups at the both 4-position and 6-position largely affect inhibitory activity. The docking model exhibited that the effective interactions of 1H-indazoles with ferrous ion of heme and key residues of hydrophobic Pocket A and B ensured the IDO1 inhibitory activities. The study suggested that the 1H-indazole was a novel interesting scaffold for IDO inhibition for further development.