94347-11-2

Basic information

• Product Name: H-ASP(OBZL)-OTBU HCL
• Synonyms: L-ASPARTIC ACID BETA-BENZYL ALPHA-T-BUTYL-DIESTER HYDROCHLORIDE;L-ASPARTIC ACID BETA-BENZYL ESTER ALPHA-T-BUTYL ESTER HYDROCHLORIDE;H-ASP(OBZL)-OTBU HCL;L-ASPARTIC ACID B-BENZYL A-T-BUTYL-DIESTER HYDROCHLORIDE;(S)-4-Benzyl 1-tert-butyl 2-aMinosuccinate hydrochloride;L-Aspartic acid beta-benzyl ester alfa-t-butyl ester HCl;L-Aspartic acid beta-benzyl ester alpha-tert-butyl ester hydrochloride;4-Benzyl 1-tert-butyl L-aspartate
• CAS NO: 94347-11-2
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 315.79
• Mol File: 94347-11-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 381.3±32.0 °C(Predicted)
• Appearance: White to off-white/Solid
• Density: 1.122±0.06 g/cm3(Predicted)
• PKA: 5.82±0.33(Predicted)
• CAS DataBase Reference: H-ASP(OBZL)-OTBU HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP(OBZL)-OTBU HCL(94347-11-2)
• EPA Substance Registry System: H-ASP(OBZL)-OTBU HCL(94347-11-2)

Safety Data

• Hazardous Substances Data: 94347-11-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 2177-63-1 (S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid 
• 2886-33-1 dibenzyl L-aspartate toluene-4-sulphonate 
• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 
• 168261-64-1 (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)succinic acid 4-benzyl ester 1-tert-butyl ester 
• 100-39-0 benzyl bromide 
• 129460-09-9 Fmoc-Asp-O-t-Bu 

Downstream Products

• 122241-38-7 N-(N-benzyloxycarbonyl-L-valyl)-L-aspartic acid-4-benzyl ester-1-tert-butyl ester 
• 4125-93-3 (S)-3-amino-4-(tert-butoxy)-4-oxobutanoic acid 
• 128576-65-8 (2S)-4-benzyl 1-tert-butyl N-benzylaspartate 
• 128576-66-9 (2S)-4-benzyl 1-tert-butyl N,N-dibenzylaspartate 
• 125989-83-5 4-Benzyl 1-t-Butyl N-Ethoxycarbonylmethyl-L-aspartate 
• 111836-07-8 (S)-2-(Cyclohex-2-enylamino)-succinic acid 4-benzyl ester 1-tert-butyl ester 
• 26055-01-6 Z-Asn-Asp(OBzl)-OtBu 
• 171356-96-0 N-chloroacetyl-L-aspartate de β-benzyle et α-tertiobutyle 
• 80963-08-2 N-tert-butoxycarbonyl-L-aspartic acid β-benzyl α-tert-butyl diester 
• 168261-64-1 (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)succinic acid 4-benzyl ester 1-tert-butyl ester 
• 873200-45-4 N-(tert-butyloxycarbonylmethyl)-L-aspartic acid-β-benzyl-α-tert-butyl ester 
• 945245-54-5 N-(fluorenyl-9-methoxycarbonyl)-L-(p-sulfomethyl)phenylalanyl-L-(4-O-benzyl)-aspartic acid α-tert-butyl ester 
• 171357-04-3 O,O-diethyl-N-phosphonoacetyl-L-aspartate de β-benzyle et de α-tertiobutyle 
• 269733-21-3 N,N-Bis(tert-butoxycarbonyl)-L-aspartic acid β-benzyl α-tert-butyl diester 

Relevant articles and documents

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors

The molecular determinants for the activities of the reported benzoic acid (SH4-54), salicylic acid (BP-1-102), and benzohydroxamic acid (SH5-07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an N-met

Synthesis of bifunctional chelating agents based on mono and diphosphonic derivatives of diethylenetriaminepentaacetic acid

Bifunctional chelating agents (BFCAs) are small molecules containing a chelating unit, able to strongly coordinate a metal ion, and a reactive functional group, devised to form a stable covalent bond with another molecule. BFCAs are widely employed since their conjugation to a suitable biomolecule (e.g., a peptide or an antibody) allows the synthesis of diagnostic or therapeutic agents that specifically target diseased tissue with metals or radiometals. For this reason, BFCAs find application in diagnostic imaging, molecular imaging, and radiotherapy of cancer. The synthesis of new BFCAs based on a diethylenetriaminepentaacetic acid (DTPA) structure in which one or two carboxylic groups are replaced with phosphonic units is described. The phosphonic group, aside from being a classical isostere of the carboxylic acid in coordination chemistry, allows to modulate the physico-chemical properties of the ligands and of the corresponding complexes.

The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.