944746-01-4

Basic information

• Product Name: 2-(2,4-difluorophenyl)-7-methyl-3H-imidazo[4,5-b]pyridine
• Synonyms: 2-(2,4-difluorophenyl)-7-methyl-3H-imidazo[4,5-b]pyridine
• CAS NO: 944746-01-4
• Molecular Weight: 245.231
• Mol File: 944746-01-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2,4-difluorophenyl)-7-methyl-3H-imidazo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-difluorophenyl)-7-methyl-3H-imidazo[4,5-b]pyridine(944746-01-4)
• EPA Substance Registry System: 2-(2,4-difluorophenyl)-7-methyl-3H-imidazo[4,5-b]pyridine(944746-01-4)

Safety Data

• Hazardous Substances Data: 944746-01-4(Hazardous Substances Data)

Upstream product

• 53929-59-2 4-methyl-2,3-diaminopyridine 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 

Relevant articles and documents

Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors

Design, synthesis and biological evaluation of the imidazopyridine analogs as novel GSK3β inhibitors for treatment of type 2 diabetes mellitus are described. Most of the analogs exhibited excellent inhibitory activities (IC50 44 nM) against glycogen synthase kinase 3β (GSK3β). The structure-activity relationship (SAR) of the imidazopyridine analogs and the binding mode of analog 23 in the catalytic domain of GSK3β, based on our X-ray crystallography study, are described. In particular, analog 28, which was selected as a potential drug candidate for treatment of type 2 diabetes mellitus, exhibited excellent GSK3β inhibition, pharmacokinetic profiles and blood glucose lowering effect in mouse.