944836-02-6 Usage
Description
(R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole is a complex chemical compound featuring a cyclohexyl group, a diphenylphosphino group, and an oxazole ring. This versatile molecule has been explored for its potential applications in asymmetric catalysis and as a ligand in organometallic chemistry, with the oxazole ring suggesting possible pharmaceutical potential due to the known biological activities of oxazole-containing compounds.
Uses
Used in Asymmetric Catalysis:
(R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole is used as a ligand in asymmetric catalysis for enhancing the selectivity and efficiency of chemical reactions. Its unique structure allows for the creation of chiral catalysts, which are crucial in the synthesis of enantiomerically pure compounds, particularly in the pharmaceutical industry.
Used in Organometallic Chemistry:
In organometallic chemistry, (R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole serves as a ligand, facilitating the formation and stabilization of organometallic complexes. These complexes are essential in various chemical reactions and can be used to study the properties and reactivity of metal centers.
Used in Pharmaceutical Research:
(R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole is used as a potential candidate in pharmaceutical research due to the presence of the oxazole ring, which is common in biologically active compounds. (R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole may be further investigated for its potential therapeutic applications, including the development of new drugs targeting various diseases.
Used in Coordination Chemistry:
In coordination chemistry, (R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole is used as a ligand to form coordination complexes with metal ions. These complexes can be employed in various applications, such as catalysts, sensors, and materials with unique properties.
Used in Chemical Synthesis:
(R)-4-cyclohexyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole can be used as an intermediate or building block in the synthesis of more complex molecules, particularly in the fields of pharmaceuticals, agrochemicals, and materials science. Its unique structure and functional groups make it a valuable component in the development of novel compounds with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 944836-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,8,3 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 944836-02:
(8*9)+(7*4)+(6*4)+(5*8)+(4*3)+(3*6)+(2*0)+(1*2)=196
196 % 10 = 6
So 944836-02-6 is a valid CAS Registry Number.
944836-02-6Relevant articles and documents
Enantioselective decarboxylative alkylation reactions: Catalyst development, substrate scope, and mechanistic studies
Behenna, Douglas C.,Mohr, Justin T.,Sherden, Nathaniel H.,Marinescu, Smaranda C.,Harned, Andrew M.,Tani, Kousuke,Seto, Masaki,Ma, Sandy,Novak, Zoltan,Krout, Michael R.,McFadden, Ryan M.,Roizen, Jennifer L.,Enquist Jr., John A.,White, David E.,Levine, Samantha R.,Petrova, Krastina V.,Iwashita, Akihiko,Virgil, Scott C.,Stoltz, Brian M.
, p. 14199 - 14223 (2012/02/01)
α-Quaternary ketones are accessed through novel enantioselective alkylations of allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the presence of palladium complexes with various phosphinooxazoline (PHOX) ligands. Excellent yields and high enantiomeric excesses are obtained from three classes of enolate precursor: enol carbonates, enol silanes, and racemic β-ketoesters. Each of these substrate classes functions with nearly identical efficiency in terms of yield and enantioselectivity. Catalyst discovery and development, the optimization of reaction conditions, the exploration of reaction scope, and applications in target-directed synthesis are reported. Experimental observations suggest that these alkylation reactions occur through an unusual inner-sphere mechanism involving binding of the prochiral enolate nucleophile directly to the palladium center. Sly as a PHOX: The development of an enantioselective decarboxylative palladium-catalyzed allylic alkylation reaction, utilizing phosphinooxazoline ligands, is described. The catalyst is applied to a range of allyl enol carbonate, silyl enol ether, and allyl β-ketoester substrates to provide alkylated ketone products in excellent yield and good ee (see scheme). The utility of these products is demonstrated by their use in several asymmetric syntheses. Mechanistic studies are reported suggesting an unusual inner-sphere mechanism. Copyright
