945031-39-0

Basic information

• Product Name: (R)-methyl 3-(tritylthio)-2-(6-(tritylthio)hexanamido)propanoate
• Synonyms: (R)-methyl 3-(tritylthio)-2-(6-(tritylthio)hexanamido)propanoate
• CAS NO: 945031-39-0
• Molecular Weight: 750.038
• Mol File: 945031-39-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-methyl 3-(tritylthio)-2-(6-(tritylthio)hexanamido)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 3-(tritylthio)-2-(6-(tritylthio)hexanamido)propanoate(945031-39-0)
• EPA Substance Registry System: (R)-methyl 3-(tritylthio)-2-(6-(tritylthio)hexanamido)propanoate(945031-39-0)

Safety Data

• Hazardous Substances Data: 945031-39-0(Hazardous Substances Data)

Upstream product

• 3695-77-0 triphenylmethanethiol 
• 4224-70-8 6-bromohexanoic acid 
• 62675-68-7 S-(triphenylmethyl)-L-cysteine methyl ester hydrochloride 
• 80441-55-0 6-(S-tritylmercapto)hexanoic acid 
• 2799-07-7 S-trityl-L-cysteine 

Relevant articles and documents

Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228

FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.

FK228 ANALOGS AND METHODS OF MAKING AND USING THE SAME

The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred e