94535-50-9 Usage
Description
Levcromakalim, also known as BRL 38167, is a potassium channel activator and vasorelaxant. It is a member of the class of drugs known as potassium channel openers and is used in the management of hypertension in diabetes mellitus. Levcromakalim works by activating potassium channels in smooth muscle cells, leading to relaxation of the blood vessels and a reduction in blood pressure.
Uses
Used in Pharmaceutical Industry:
Levcromakalim is used as an anti-asthmatic agent for the treatment of asthma. It helps to relax the smooth muscles in the airways, improving lung function and reducing symptoms of asthma.
Used in Pharmaceutical Industry:
Levcromakalim is used as an antihypertensive agent for the management of hypertension in diabetes mellitus. It helps to lower blood pressure by relaxing the blood vessels, reducing the workload on the heart and improving blood flow.
Used in Pharmaceutical Industry:
Levcromakalim is used as a vasorelaxant for the treatment of various cardiovascular conditions. Its ability to relax blood vessels can help to improve blood flow and reduce the risk of heart disease and stroke.
Biological Activity
Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.
Check Digit Verification of cas no
The CAS Registry Mumber 94535-50-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,5,3 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 94535-50:
(7*9)+(6*4)+(5*5)+(4*3)+(3*5)+(2*5)+(1*0)=149
149 % 10 = 9
So 94535-50-9 is a valid CAS Registry Number.
94535-50-9Relevant articles and documents
CONTROLLED-DELIVERY CROMAKALIM PRODRUGS
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, (2021/06/22)
The present invention provides cromakalim prodrugs, compositions, and their use for the modulation of ATP-sensitive potassium (KATP) channels for therapeutic purposes.
Chiral Manganese Aminopyridine Complexes: the Versatile Catalysts of Chemo- and Stereoselective Oxidations with H2O2
Ottenbacher, Roman V.,Talsi, Evgenii P.,Bryliakov, Konstantin P.
, p. 78 - 90 (2017/10/06)
In the last decade, manganese(II) complexes with N-donor tetradentate aminopyridine ligands emerged as efficient catalysts of enantioselective epoxidation of olefins and direct selective oxidation of C?H groups in complex organic molecules, with environmentally benign oxidant hydrogen peroxide. In this personal account, we summarize the progress of these catalysts with regard to ligands design, structure-reactivity correlations, evaluation of the substrate scope, as well as mechanistic studies, shedding light on the nature of active sites and the mechanisms of selective oxygenations. Several practically promising catalytic syntheses with the aid of Mn aminopyridine catalysts are exemplified.
Immobilized dimeric chiral Mn(III) salen complex on short channel ordered mesoporous silica as an effective catalyst for the epoxidation of non-functionalized alkenes
Roy, Tamal,Kureshy, Rukhsana I.,Khan, Noor-Ul H.,Abdi, Sayed H.R.,Sadhukhan, Arghya,Bajaj, Hari C.
, p. 6314 - 6322 (2012/08/28)
Chiral dimeric Mn(III) salen complex with 1R, 2R-(-)-diaminocyclohexane collar was immobilized on short channel large pore sized silica through a long linker of {(CH2)3-NH-melamine-piperazine} to investigate its performance in enanti
