94569-84-3

Basic information

• Product Name: 2-Bromo-5-fluorobenzaldehyde
• Synonyms: 2-BROMO-5-FLUOROBENZALDEHYDE;5-Fluoro-2-Bromo benzaldehyde;2-BROMO-5-FLUOROBENZALDHYDE;2-Bromo-5-fluorobenzaldehyde ,98%;Benzaldehyde, 2-broMo-5-fluoro-;2-BroMo-5-fluorobenzaldehyde, 95+%;2-Bromo-5-fluorobenzaldehyde 96%
• CAS NO: 94569-84-3
• Molecular Formula: C₇H₄BrFO
• Molecular Weight: 203.01
• EINECS: 1592732-453-0
• Product Categories: Aldehydes;blocks;FluoroCompounds;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);Furans, Benzofurans & Dihydrobenzofurans;Phenyls & Phenyl-Het;Benzaldehyde;API intermediates;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Phenyls & Phenyl-Het;Furans, Benzofurans & Dihydrobenzofurans;C7;Carbonyl Compounds;Benzaldehyde series;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Ipragliflozin
• Mol File: 94569-84-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 51-56 °C(lit.)
• Boiling Point: 225.8 °C at 760 mmHg
• Flash Point: 190 °F
• Appearance: /
• Density: 1.67 g/cm³
• Vapor Pressure: 0.0845mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• Solubility: Soluble in methanol.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Bromo-5-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorobenzaldehyde(94569-84-3)
• EPA Substance Registry System: 2-Bromo-5-fluorobenzaldehyde(94569-84-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 94569-84-3(Hazardous Substances Data)

Usage

Description

2-Bromo-5-fluorobenzaldehyde is an organic compound characterized by a benzene ring with a bromine atom at the 2nd position and a fluorine atom at the 5th position, along with an aldehyde functional group. It is a white to light yellow solid that can be synthesized by reacting 2-bromo-5-fluorotoluene with N-bromosuccinimide. Its crystals exhibit a monoclinic crystal system and space group P21/c.

Uses

Used in Material Science:
2-Bromo-5-fluorobenzaldehyde is used as a precursor for the synthesis of 5-fluoro-3-substituted benzoxaboroles, which serve as molecular receptors, building blocks in crystal engineering, and steroid conjugates for molecular imprinting. These benzoxaboroles are also utilized in the development of dyes and biosensors for alpha-hydroxyl carboxylic acids.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Bromo-5-fluorobenzaldehyde is used in the synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-one by reacting with 2-amino-N'-arylbenzohydrazide in the presence of Copper(I) bromide through a Ullmann-type reaction. This synthesized compound may have potential applications in drug discovery and development.
Used in Organic Synthesis:
2-Bromo-5-fluorobenzaldehyde may also be used in the synthesis of dihydrobenzoxaboroles bearing aryl, heteroaryl, or vinyl substituents at the 1-position and 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole. These compounds can be employed as intermediates in the development of various organic compounds and materials.

InChI:InChI=1/C7H4BrFO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

Upstream product

• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 543730-68-3 3-fluorobenzaldehyde O-methyloxime 
• 456-48-4 3-Fluorobenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 
• 739336-26-6 2-(2-bromo-5-fluorophenyl) acetic acid 
• 1069115-12-3 methyl 2-(2-bromo-5-fluorophenyl)acetate 
• 866029-28-9 2-(2-bromo-5-fluorophenyl)ethan-1-ol 

Downstream Products

• 94569-81-0 2-[(E)-2-(2-Bromo-5-fluoro-phenyl)-vinyl]-naphthalene 
• 94569-79-6 7-[(E)-2-(2-Bromo-5-fluoro-phenyl)-vinyl]-1-fluoro-naphthalene 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 904744-84-9 1-bromo-4-fluoro-2-(2-methyl-propenyl)-benzene 
• 906673-56-1 1-(2′-bromo-5′-fluorophenyl)ethan-1-ol 
• 905710-67-0 2-bromo-5-fluoro-[1-(methoxymethoxy)ethyl]benzene 
• 905710-81-8 2-(2-bromo-5-fluorophenyl)acetaldehyde 
• 845301-93-1 2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene 
• 943835-77-6 5-fluoro-2-(2-phenylethynyl)benzaldehyde 
• 174671-46-6 tavaborole 

Relevant articles and documents

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

Based on 4 - phenyl -6 - (2, 2, 2 - trifluoro -1 - phenyl ethoxy) pyrimidine compound and its application method

The present invention relates to compounds based on 4-phenyl-6-(2,2,2-trifluoro-1-phenyl ethoxy) pyrimidine and an application method thereof, particularly discloses compounds of formula I and compositions comprising the compounds, and the application method thereof in treatment, prevention and / or management of diseases or disorders.

A gold catalytic oxidation of benzyl alcohol synthesis method (by machine translation)

The present invention provides a kind of organic synthesis in the oxidation of benzyl alcohol synthesis method, the reaction formula is as follows, in the formula 1 containing different substituents is benzyl alcohol, in the formula 2 is triphenylcarbinol compound. The required reaction of gold catalyst is Ph3 PAuCl, Ph3 PAuNTf2 , HAuCl4 , NaAuCl4 , Ph3 PAuOTf, Ph3 PAuSbF6 , IPrAuCl, gold. The required reaction medium is: solvent-free, toluene, are three-toluene, 1, 2 - dichloroethane, tetrahydrofuran, acetonitrile, acetone. The reaction implementing microwave heating of reactor, the method of the invention the oxidizing agent triphenylcarbinol for commercial products, cheap, and simple experimental operation, substrate and wide range of application. (by machine translation)