945732-76-3

Basic information

• Product Name: N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide
• Synonyms: N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide
• CAS NO: 945732-76-3
• Molecular Weight: 631.456
• Mol File: 945732-76-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide(945732-76-3)
• EPA Substance Registry System: N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide(945732-76-3)

Safety Data

• Hazardous Substances Data: 945732-76-3(Hazardous Substances Data)

Upstream product

• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 
• 56-54-2 quinidine 

Downstream Products

• 1415666-62-4 N-(3,5-ditrifluoromethylbenzyl)quinidinium fluoride 
• 1415666-65-7 N-(3,5-ditrifluoromethyl)benzyl-O-⁽⁹⁾-(3,5-ditrifluoro-methylbenzyl)quinidinium bromide 

Relevant articles and documents

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

A highly enantioselective nucleophilic addition of ketones to imines catalyzed by chiral phase-transfer catalysts (N-quaternised cinchona alkaloid ammonium salts) has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields (up to 95%) with excellent enantioselectivities (up to 97% ee).

Catalytic asymmetric conjugate addition of isocyanoacetate to (Z)-3-substituted-2-(4-pyridyl)-acrylonitrile, a reactive class of Michael acceptor

(Z)-3-Substituted-2-(4-pyridyl)-acrylonitriles, a reactive class of Michael acceptors obtained exclusively as a single (Z) isomer, reacted with un-substituted isocyanoacetate esters mediated by phase-transfer catalysis to give, after base promoted cyclisation, functionalized imines in up to 94% ee and as a single diastereoisomer.

Diastereoselective and enantioselective epoxidation of acyclic β-trifluoromethyl-β,β-disubstituted enones by hydrogen peroxide with a pentafluorinated quinidine-derived phase-transfer catalyst

An efficient catalytic asymmetric epoxidation of β-trifluoromethyl- β,β-disubstituted unsaturated ketones has been achieved by a pentafluorine-substituted phase-transfer catalyst with hydrogen peroxide (30%). Thus, the β-trifluoromethyl-α,β-epoxy ketones with a quaternary carbon centre were obtained in excellent diastereoselectivities (up to 100:1 dr) and excellent enantioselectivities (up to 99.7% ee). Low catalyst loading, recycle of catalyst, environmentally benign oxidant and easy transformation of the epoxides into medicinally important trifluoromethylated intermediate make our protocol much more practical. Copyright