94594-91-9Relevant articles and documents
ASYMMETRISCHE INDUKTION BEI DER NI(0)-KATALYSIERTEN -CYCLOADDITION VON CAMPHERSULTAMACRYLAT MIT METHYLENCYCLOPROPANEN
Binger, Paul,Schaefer, Bernd
, p. 529 - 530 (1988)
The asymmetric Ni(0)-catalyzed cycloaddition of (-)-camphorsultamacrylate with methylenecyclopropane or 2,2-dimethylmethylenecyclopropane leads to 3-methylenecyclopentanecarboxylic amides in high optical yields up to 98percent de.
CONJUGATE OF CELL-BINDING RECEPTOR WITH CYTOTOXIC AGENT
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Page/Page column 129, (2017/10/31)
PROBLEM TO BE SOLVED: To provide a conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule for targeted treatment. SOLUTION: According to the present invention, there is provided a conjugate having a structure of formula (I) and a pharmaceutical acceptable salt and a solvate thereof. The conjugate is used for treating cancer, autoimmune disease, and infectious disease. (T is a targeting or binding ligand; L is a releasable linker; a broken line is a linkage bond that L connects to a molecule inside the bracket independently; n is an integer of 1 to 20; m is an integer of 1 to 10; and a structure in parentheses is a potent antimitotic agent/drug.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
Diastereoselective ru-catalyzed cross-metathesis-dihydroxylation sequence. An efficient approach toward enantiomerically enriched syn-diols
Neisius, N. Matthias,Plietker, Bernd
, p. 3218 - 3227 (2008/09/19)
(Chemical Equation Presented) Sequential catalysis has evolved as a powerful concept within the past years and allows the more efficient use of catalytically active expensive transition metals in organic synthesis. In this paper we present the stereoselective cross-metathesis-dihydroxylation of various olefins with chiral auxiliary substituted acrylamides. The chiral information (i.e., the auxiliary) introduced in the metathesis reactions allows for a stereoselective subsequent RuO4-catalyzed dihydroxylation. The sequence is concluded by an unusual kinetic resolution of the diastereomeric diols obtained in the oxidation reaction. As a consequence a variety of structurally diverse enantiomerically enriched diols are obtained. To the best of our knowledge the results summarized in this paper represent the first highly efficient diastereoselective RuO4-catalyzed oxidation.