946134-08-3

Basic information

• Product Name: (R)-(2-methyl-dihydrothiophen-3-ylidene)(1-phenylethyl)amine
• Synonyms: (R)-(2-methyl-dihydrothiophen-3-ylidene)(1-phenylethyl)amine
• CAS NO: 946134-08-3
• Molecular Weight: 219.351
• Mol File: 946134-08-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(2-methyl-dihydrothiophen-3-ylidene)(1-phenylethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(2-methyl-dihydrothiophen-3-ylidene)(1-phenylethyl)amine(946134-08-3)
• EPA Substance Registry System: (R)-(2-methyl-dihydrothiophen-3-ylidene)(1-phenylethyl)amine(946134-08-3)

Safety Data

• Hazardous Substances Data: 946134-08-3(Hazardous Substances Data)

Upstream product

• 74015-70-6 4,5-Dihydro-2-methylthiophen-3-(2H)-on 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant articles and documents

Synthetic study toward 17-thiasteroids: synthesis of the 1-thiahydrinden-5-one subunit using a new annulation procedure and investigation of its reduction

The enantioselective syntheses of ketones 6 and 7 featuring the CD subunit of 17-thiasteroid are described. The key bicyclic 1-thiahydrindenone (S)-5 was assembled in three steps from Michael adduct (S)-12 via β-keto ester 15 using a one-pot sequential process involving cleavage of both the ketal group and the tert-butyl ester group, decarboxylation, and finally intramolecular aldol condensation. Hydridoalkyl cuprate-induced conjugate reduction of 1-thiahydrindenone (S)-5 and its corresponding sulfone (S)-23 gave 1-thiahydrindanones 6 and 7, respectively, which display unexpectedly the unnatural cis-ring junctions.