947231-56-3

Basic information

• Product Name: (R,E)-benzyl 2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoate
• Synonyms: (R,E)-benzyl 2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoate
• CAS NO: 947231-56-3
• Molecular Weight: 338.468
• Mol File: 947231-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R,E)-benzyl 2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-benzyl 2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoate(947231-56-3)
• EPA Substance Registry System: (R,E)-benzyl 2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoate(947231-56-3)

Safety Data

• Hazardous Substances Data: 947231-56-3(Hazardous Substances Data)

Upstream product

• 16957-70-3 2-methylpent-2-enoic acid 
• 947231-50-7 (S)-4-benzyl-3-[(R,E)-2-(3,3-dimethoxypropylthio)-2-methylpent-3-enoyl]oxazolidin-2-one 
• 100-51-6 benzyl alcohol 
• 886733-92-2 S-3,3-dimethoxypropyl methanethiosulfonate 
• 635758-46-2 (S)-3-((E)-2-methylpent-2-enoyl)-4-benzyloxazolidin-2-one 

Downstream Products

• 947231-63-2 (R,E)-benzyl 2-methyl-2-(3-oxopropylthio)pent-3-enoate 
• 947231-69-8 (R,E)-benzyl 2-methyl-2-(propionylthio)pent-3-enoate 
• 947231-77-8 (R,E)-benzyl 2-methyl-2-(acetylthio)pent-3-enoate 

Relevant articles and documents

Synthesis and biological activity of enantiomeric pairs of 5-(alk-2-enyl)thiolactomycin and 5-[(E)-cycloalk-2-enylidenemethyl] thiolactomycin congeners

The title compounds were synthesized by the efficient route previously explored for the synthesis of enantiomeric pairs of thiolactomycin and its 3-demethyl derivative. These studies were carried out to prove the flexibility of the previously explored synthetic route to natural thiolactomycin (TLM) 1 and to examine the structure-activity relationship on the 5-position of 1. While all of the synthesized congeners lacked in vitro antibacterial activity, these studies led us to find 5-(alk-2-enyl)-TLM (ent-4d) which exhibits mammalian type I fatty acid synthase (FAS) inhibitory activity equal to that of C75, a potent inhibitor reported previously. It was also found that 5-[(E)-cycloalk-2- enylidenemethyl]-TLM (ent-5c) exhibited slightly less potent mammalian type I FAS inhibitory activity than C75.