947674-94-4

Basic information

• Product Name: 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol)
• Synonyms: 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol);4-MorpholinecarboxaMide, N-(2-aMinoethyl)-, ethanedioate
• CAS NO: 947674-94-4
• Molecular Formula: C9H17N3O6
• Molecular Weight: 263.25
• Product Categories: APIs Intermediate
• Mol File: 947674-94-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol)(947674-94-4)
• EPA Substance Registry System: 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol)(947674-94-4)

Safety Data

• Hazardous Substances Data: 947674-94-4(Hazardous Substances Data)

Usage

General Description

Landiolol, also known as 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate, is a chemical compound used as a short-acting intravenous beta blocker. It works by blocking the action of adrenaline on the heart and blood vessels, resulting in a decrease in heart rate and blood pressure. This makes it useful in the management of tachyarrhythmias and hypertension. The compound is often administered in a hospital setting for the treatment of acute conditions, such as rapid heart rhythms or high blood pressure, and is known for its rapid onset and short duration of action. Landiolol is considered to be a valuable option for quickly controlling heart rate and blood pressure in various clinical situations.

Upstream product

• 144-62-7 oxalic acid 
• 93605-74-4 4-[(1H-imidazol-1-yl)carbonyl]morpholine 
• 107-15-3 ethylenediamine 

Downstream Products

• 69630-16-6 N-(2-aminoethyl)-4-morpholine carboxamide 
• 133242-30-5 2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-<4-<3-<2-(morpholinocarbonylamino)ethylamino>-2S-hydroxypropoxy>phenyl>propionate 
• 1253907-79-7 landiolol hydrochloride 

Relevant articles and documents

Preparation method of landiolol hydrochloride intermediate

The invention discloses a preparation method of a high-purity landiolol hydrochloride intermediate N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. The preparation method comprises the following steps: reacting N-phenoxy carbonyl morpholine with ethylenediamine, concentrating the reaction liquid, adding a solvent for dissolving, adjusting the pH value to 9-14 by using alkali, filtering to remove solid byproducts, concentrating the filtrate to obtain N-(2-aminoethyl)-4-morpholine formamide, adding water for dissolving, adjusting the pH value to 1-6 by using oxalic acid, filtering to remove a small amount of ethylenediamine oxalate solid, concentrating the filtrate, adding a solvent, and recrystallizing to obtain the high-purity N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. According to the method, the high-purity landiolol hydrochloride intermediate can be obtained, the defects that the byproduct sodium phenate is difficult to filter, ethylenediamine is easy to remain and the like are overcome, the process is stable and controllable, the solvent can be recycled, and the method is more suitable for industrial production.