949570-75-6Relevant articles and documents
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1, 4]diazepin-11-one-based potent and selective Chk-1 inhibitors
Wang, Le,Sullivan, Gerard M.,Hexamer, Laura A.,Hasvold, Lisa A.,Thalji, Reema,Przytulinska, Magdalena,Tao, Zhi-Fu,Li, Gaoquan,Chen, Zehan,Xiao, Zhan,Gu, Wen-Zhen,Xue, John,Bui, Mai-Ha,Merta, Philip,Kovar, Peter,Bouska, Jennifer J.,Zhang, Haiying,Park, Chang,Stewart, Kent D.,Sham, Hing L.,Sowin, Thomas J.,Rosenberg, Saul H.,Lin, Nan-Horng
, p. 4162 - 4176 (2008/02/13)
A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the
