949898-58-2

Basic information

• Product Name: (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol
• Synonyms: (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol
• CAS NO: 949898-58-2
• Molecular Formula: C₆H₇F₃N₂O
• Molecular Weight: 180.1277896
• Mol File: 949898-58-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol(949898-58-2)
• EPA Substance Registry System: (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol(949898-58-2)

Safety Data

• Hazardous Substances Data: 949898-58-2(Hazardous Substances Data)

Usage

General Description

(1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol is a chemical compound with the molecular formula C7H8F3N3O. It is a pyrazole derivative with a methyl and trifluoromethyl group attached to the nitrogen atom. (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol has potential applications in the fields of pharmaceuticals and agrochemicals due to its ability to act as a building block in the synthesis of various biologically active molecules. Additionally, the presence of the trifluoromethyl group in the structure can lead to enhanced biological activity and metabolic stability of the resulting compounds. However, further research is needed to fully understand the potential uses and properties of this chemical.

Upstream product

• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 
• 60-34-4 methylhydrazine 

Downstream Products

• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 

Relevant articles and documents

Synthesis of functionalized fluoroalkyl pyrimidines and pyrazoles from fluoroalkyl enones

The synthesis of a series of polyfluoromethyl-substituted pyrimidines and pyrazoles bearing potential for further functionalization of the hydroxymethyl group prepared from the fluoroalkyl-containing enones with isothioureas, amidine and hydrazines, is reported. We investigated the deoxyfluorination of hydroxymethyl group in polyfluoromethyl containing pyrazoles and obtained di- and trifluoromethyl pyrazoles with an additional monofluoromethyl group.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50 = 35-145 nM) inhibitor against multiple primary isolates of diverse measles vir