95061-51-1

Basic information

• Product Name: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE
• Synonyms: (S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate,99%;(S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate(S)-(-)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate;(S)-(-)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate, 98+%;(S)-(-)-HYTRA;(S)-(-)-2-Hydroxy-1,2,3-triphenylethyl acetate;(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL A;(1S)-2-Hydroxy-1,2,2-triphenylethyl acetate;(S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate for synthesis
• CAS NO: 95061-51-1
• Molecular Formula: C₂₂H₂₀O₃
• Molecular Weight: 332.39
• Product Categories: chiral;Chiral Compound
• Mol File: 95061-51-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 246-249 °C
• Boiling Point: 429.52°C (rough estimate)
• Flash Point: 197.557 °C
• Appearance: white to light yellow crystal powder
• Density: 1.180
• Vapor Pressure: 2.53E-10mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 12.40±0.29(Predicted)
• CAS DataBase Reference: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(95061-51-1)
• EPA Substance Registry System: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(95061-51-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: WGK 3 highly water endangering
• Hazardous Substances Data: 95061-51-1(Hazardous Substances Data)

Usage

Description

(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE, also known as (S)-2-Hydroxy-1,2,2-triphenylethyl Acetate, is a white to light yellow crystalline powder. It is a chiral compound with a specific stereochemistry, where the hydroxyl group is attached to the carbon atom in the S configuration. This unique structure makes it a valuable intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE is used as a reactant in the synthesis of Lankacidin derivatives, which are 17-membered macrocyclic antibiotics. These antibiotics exhibit potent antimicrobial activity against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The unique macrocyclic structure of Lankacidin derivatives allows them to target specific bacterial proteins, leading to their potent and selective antimicrobial action.

InChI:InChI=1/C22H20O3/c1-17(23)25-21(18-11-5-2-6-12-18)22(24,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24H,1H3/t21-/m0/s1

Upstream product

• 108998-83-0 (S)-1,1,2-triphenyl-1,2-ethanediol 
• 75-36-5 acetyl chloride 
• 108-86-1 bromobenzene 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 17199-29-0 (S)-Mandelic acid 
• 21210-43-5 (S)-Methyl mandelate 

Downstream Products

• 147986-42-3 (S)-4-Bromo-3-hydroxy-4-pentenoic acid (S)-1,2,2-triphenyl-2-hydroxyethyl ester 
• 126832-13-1 (1'S,3S)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 126832-13-1 (1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 118219-45-7 (3S,4S)-4-Benzyloxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 58521-49-6 (3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid 
• 66967-01-9 (3R,4S)-3-hydroxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methylheptanoic acid 
• 128013-71-8 (4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 128013-71-8 (3S,4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 128053-07-6 (3R,4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 118219-44-6 (3S,4S)-4-tert-Butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 116386-66-4 (E)-(3S,4R,5S)-3-Hydroxy-7-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-hept-6-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 115407-88-0 (1'S,3R,5S)-3,5,6-trihydroxy-5,6-O-isopropylidenehexanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 115407-87-9 (1'S,3S,5S)-3,5,6-trihydroxy-5,6-O-isopropylidenehexanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 129600-88-0 (Z)-(S)-4-Fluoro-3-hydroxy-6-phenyl-hex-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 

Relevant articles and documents

Total Synthesis of (-)-Disorazole C1

Disorazoles represent a powerful class of highly potent antitubulin natural products isolated from myxobacteria. Herein, we describe a scalable and robust synthesis of (-)-disorazole C1 with high stereoselectivity, featuring quite simple reaction conditio

AN EFFICIENT LARGE SCALE PREPARATION OF (S)-1,1,2-TRIPHENYLETHANEDIOL 2-ACETATE

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Synthetic studies of the detoxin complex. I. Total synthesis of (-) detoxinine

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