95076-93-0

Basic information

• Product Name: CYCLOPHILIN A
• Synonyms: EC 5.2.1.8;CYCLOPHILIN;CYCLOPHILIN A;CYCLOPHILIN A (HUMAN);CYCLOPHILIN HUMAN;PEPTIDYLPROLINE CIS-TRANS-ISOMERASE;CYCLOPHILIN HUMAN, RECOMBINANTEXPRESSED IN E. COLI;CYCLOPHILIN FROM CALF THYMUS
• CAS NO: 95076-93-0
• Molecular Weight: 0
• Mol File: 95076-93-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /buffered aqueous solution
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CYCLOPHILIN A(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPHILIN A(95076-93-0)
• EPA Substance Registry System: CYCLOPHILIN A(95076-93-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 95076-93-0(Hazardous Substances Data)

Usage

Description

Cyclophilin A (CyPA) is a 20 kDa chaperone protein that belongs to the cyclophilin family of immunophilins. It is extremely conserved and present in all tissues of prokaryotes and eukaryotes, including all organs of the human body. CyPA is liberated from vascular smooth muscle cells (VSMCs) and plays a crucial role in various biological processes.

Uses

Used in Pharmaceutical Industry:
Cyclophilin A is used as a target for drug development in the pharmaceutical industry. Its involvement in various cellular processes, such as protein folding, immune response, and inflammation, makes it a promising candidate for the development of therapeutic agents.
Used in Biomedical Research:
Cyclophilin A is used as a research tool in biomedical research to study the mechanisms of extracellular CyPA in initiating endothelial activation. Understanding its role in this process can provide insights into the development of new therapeutic strategies for various diseases.
Used in Diagnostics:
Cyclophilin A can be used as a biomarker in diagnostics to detect and monitor certain diseases. Its presence in various tissues and organs makes it a potential indicator of disease progression or response to treatment.
Used in Drug Delivery Systems:
Cyclophilin A can be employed in drug delivery systems to improve the efficacy and targeting of therapeutic agents. Its ability to interact with various proteins and cellular processes can be leveraged to enhance drug delivery and bioavailability.

Biochem/physiol Actions

Cyclophilin A (CyPA) participates in intracellular signalling and protein trafficking. It helps to control other proteins activity. CyPA plays a physiological and pathological role in cardiovascular diseases. Hence it acts as an important biomarker and mediator in several cardiovascular diseases, like vascular stenosis, atherosclerosis and abdominal aortic aneurysms.?CyPA can induce the proliferation and inflammatory cell migration of vascular smooth muscle cells (VSMC) in vitro and in vivo.