95088-64-5Relevant articles and documents
Electrostatic effects in acylation of hemoglobin by aspirins
Massil,Shi,Klotz
, p. 1851 - 1853 (1984)
Carboxylate substituents added to the salicylate ring increase the effectiveness of a variety of aspirins and diaspirins in acylating hemoglobin. Even more effective are a series of monoesters of dicarboxylate derivatives. Bis(5-carbomethoxysalicyl)fumarate and -succinate at 5 mM concentrations modify ~100% of the hemoglobin in solution and should alter the aggregation behavior of sickle hemoglobin.