952151-38-1

Basic information

• Product Name: 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate
• Synonyms: 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate
• CAS NO: 952151-38-1
• Molecular Weight: 336.388
• Mol File: 952151-38-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate(952151-38-1)
• EPA Substance Registry System: 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate(952151-38-1)

Safety Data

• Hazardous Substances Data: 952151-38-1(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 72791-76-5 bis(2-chloroethyl)carbamic acid benzyl ester 
• 133024-90-5 N-benzyloxycarbonyldiethanolamine dimesylate 

Downstream Products

• 952151-39-2 [1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 952153-89-8 C₁₂H₁₆N₂O₃ 
• 952151-47-2 C₂₁H₂₆F₄N₄O₆ 
• 952151-46-1 C₂₁H₂₈F₂N₄O₆ 
• 952151-44-9 C₂₀H₂₇F₂N₃O₈S 
• 952151-45-0 5(R)-(azidomethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952151-42-7 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 952151-43-8 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952153-90-1 C₁₈H₁₇F₂N₃O₅ 
• 952151-41-6 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Heterocyclic Compound

The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Synthesis and application of [1,2,5]triazepane and [1,2,5]oxadiazepane as versatile structural units for drug discovery

Seven-membered heterocyclic [1,2,5]triazepane and [1,2,5]-oxadiazepane derivatives were synthesized as candidate structures for application in drug discovery in place of conventional piperazine or morpholine moieties, offering multiple sites for modification with functional groups. We first synthesized the Nprotected heterocycles, and then confirmed their utility by synthesizing analogues of the oxazolidinone antibacterial agent linezolid. The analogues exhibited potent in vitro and in vivo antibacterial activity. In particular, compound 10a exhibited good in vivo efficacy when administered intravenously in a murine model of systemic infection with methicillin-resistant Staphylococcus aureus SR3637. These seven-membered heterocycles are expected to be versatile structural units for drug discovery.

NOVEL COMPOUND HAVING HETEROCYCLIC RING

The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, -O-, -S-, -NR2-, -CO-, -CS-, - CONR3-, -NR4CO-, -SO2NR5-, and -NR6SO2- (wherein R2 - R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.