95233-37-7

Basic information

• Product Name: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid
• Synonyms: CPCCA;(E)-4-(4-Chlorophenyl)cyclohexanecarboxylic acid;4-(4-Chlorophenyl)cyclohexylcarboxylic acid;4-(4'-Chlorophenyl)cyclohexancarboxylicacid;4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN[FOR TAZAROTENE];4-(4-Chlorophenyl)cyclohexanecarboxylic acid;4-(P-CHLOROPHENYL)CYCLOHEXANECARBOXYLICACID;4-(trans-4-Carboxycyclohexyl)chlorobenzene
• CAS NO: 95233-37-7
• Molecular Formula: C₁₃H₁₅ClO₂
• Molecular Weight: 238.71
• Mol File: 95233-37-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 387.1 °C at 760 mmHg
• Flash Point: 187.9 °C
• Appearance: /
• Density: 1.225 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.80±0.10(Predicted)
• CAS DataBase Reference: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(95233-37-7)
• EPA Substance Registry System: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(95233-37-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39-22
• Hazardous Substances Data: 95233-37-7(Hazardous Substances Data)

Usage

Description

4-(4-Chlorophenyl)cyclohexanecarboxylic acid is an organic compound characterized by the presence of a cyclohexane ring and a 4-chlorophenyl group attached to the carboxylic acid functional group. This unique molecular structure endows it with specific chemical properties that make it a versatile building block in the synthesis of various chemical entities.

Uses

Used in Pharmaceutical Industry:
4-(4-Chlorophenyl)cyclohexanecarboxylic acid is used as a reactant for the synthesis of novel hydrazone derivatives, which are known for their antimicrobial properties. These hydrazone derivatives can be further developed into potential antimicrobial agents, addressing the growing need for new antibiotics and antifungal drugs to combat drug-resistant infections.
In the synthesis process, 4-(4-Chlorophenyl)cyclohexanecarboxylic acid can be combined with hydrazine or its derivatives to form the desired hydrazone compounds. The resulting hydrazone derivatives can exhibit broad-spectrum antimicrobial activity, making them valuable candidates for further research and development in the pharmaceutical field.

Upstream product

• 49708-48-7 4-(4-Chloro-phenyl)-cyclohex-3-enecarboxylic acid 
• 106-39-8 bromochlorobenzene 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 91161-85-2 trans-4-(p-chlorophenyl)-1-acetyl-cyclohexane 
• 3618-03-9 methyl 4-hydroxycyclohexanecarboxylate 
• 128208-09-3 methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate 

Downstream Products

• 129719-64-8 2-[4-(4-chlorophenyl)-cyclohexyl]-3-chloro-1,4-naphthoquinone 
• 128208-09-3 methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate 
• 1228658-09-0 4-(4-chlorophenyl)cyclohexanecarbaldehyde 
• 1228657-97-3 C₁₇H₂₄ClNO 
• 94015-53-9 atovaquone 
• 829-32-3 1-chloro-4-cyclohexylbenzene 

Relevant articles and documents

A pharmaceutical intermediate 4 - (4 - chlorophenyl) cyclohexyl -1 - formic acid

The invention belongs to the field of preparation of drug intermediates and particularly relates to a synthesis method of a drug intermediate 4-(4-chlorphenyl) cyclohexyl-1-formic acid. The method comprises the following steps: firstly reacting a compound I with R2SO2Cl in the presence of an acid-binding agent to obtain a compound II; carrying out catalytic coupling reaction on the compound II and a Grignard reagent 4-chlorphenyl magnesium halide under the action of a catalyst to obtain a compound III; and finally hydrolyzing the compound III in alkali liquor to obtain a target product 4-(4-chlorphenyl) cyclohexyl-1-formic acid. According to the synthesis method, all steps in a reaction route are exclusive reactions; and ortho-position and meta-position problems in friedel-crafts reaction are overcome, so that the utilization rate of raw materials is high; the total yield is high; and the cost is low. A main body structure is constructed by a coupling technique, so that the problem that hydrolysate which is formed after a lot of lewis acid used in the friedel-crafts reaction is hydrolyzed needs to be subjected to special treatment is overcome; the method is environment-friendly; and industrialized production is facilitated.

Method for treating animals infected with Babesia spp.

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of protozoal infections caused by Kinetoplastida, Apicomplexa, Anaerobic protozoa and Mircosporidia comprising 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt or other functional derivative thereof as active ingredient and to a method of treating or preventing siad protozoal infections in an animal which comprises administering to said animal an effective amount of siad compound.

Medicaments

A method and certain compositions for treating Pneumocystis carinii infections in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.