95538-32-2

Basic information

• Product Name: 1H-INDOLE-2-CARBONYL CHLORIDE,5-BROMO
• Synonyms: 1H-INDOLE-2-CARBONYL CHLORIDE,5-BROMO;5-bromo-1H-Indole-2-carbonyl chloride
• CAS NO: 95538-32-2
• Molecular Formula: C₉H₅BrClNO
• Molecular Weight: 258.5
• Mol File: 95538-32-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-INDOLE-2-CARBONYL CHLORIDE,5-BROMO(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-2-CARBONYL CHLORIDE,5-BROMO(95538-32-2)
• EPA Substance Registry System: 1H-INDOLE-2-CARBONYL CHLORIDE,5-BROMO(95538-32-2)

Safety Data

• Hazardous Substances Data: 95538-32-2(Hazardous Substances Data)

Usage

Explanation

The compound consists of 9 carbon atoms, 6 hydrogen atoms, 1 bromine atom, 1 chlorine atom, and 1 nitrogen atom.

Explanation

The Chemical Abstracts Service (CAS) registry number is a unique identifier for this specific chemical compound.

Explanation

1H-Indole-2-carbonyl chloride,5-Bromo is derived from the indole structure, which is a core structure found in various natural and synthetic compounds.

Explanation

This compound is frequently used as a building block or intermediate in the synthesis of more complex organic molecules, particularly in the fields of pharmaceuticals and agrochemicals.

Explanation

The compound appears as a white to off-white powdery solid.

Explanation

The compound does not readily react or degrade when stored or handled under standard environmental conditions.

Explanation

1H-Indole-2-carbonyl chloride,5-Bromo serves as a valuable intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its functional groups and substituents.

Explanation

The presence of a bromine atom in the compound makes it a valuable building block for the development of new drugs and bioactive compounds, as bromine can influence the compound's properties and reactivity.

Explanation

It is important to handle 1H-Indole-2-carbonyl chloride,5-Bromo with care, as it may pose risks to human health and the environment if not properly managed.

Physical appearance

White to off-white powder

Stability

Stable under normal conditions

Upstream product

• 7254-19-5 5-bromo-2-indolecarboxylic acid 

Downstream Products

• 103343-97-1 1,3-Dihydro-3-(RS)-(5-Bromoindole-2-carbonylamino)-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one 
• 1278517-86-4 1-(5-phenyl-1H-indol-2-yl)-2-(pyridin-3-yl)-ethan-1-one 

Relevant articles and documents

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of hit compound 7 and conduct further structure-activity relationship (SAR) studies that result in the development of compound 19 with a novel indole-2-carboxamide hinge scaffold. Compound 19 displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, compound 19 also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), compound 19 shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, compound 19 represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC.

INDOLES USEFUL IN THE TREATMENT OF INFLAMATION

There is provided compounds of formula (I), Wherein T, Y, X1 , R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.