95568-41-5

Basic information

• Product Name: ALPHA2-MACROGLOBULIN
• Synonyms: A2M;A-2-M, HUMAN;ALPHA2M;ALPHA2-MACROGLOBIN, HUMAN;ALPHA2-MACROGLOBULIN;ALPHA2-MACROGLOBULIN, HUMAN;ALPHA2-MACROGLOBULIN, HUMAN PLASMA;ALPHA-2 MACROGLOBULIN PLASMA
• CAS NO: 95568-41-5
• Molecular Weight: 272.7328
• Product Categories: α2-Macroglobulin;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;proteins
• Mol File: 95568-41-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Density: 1.36 g/cm³
• Storage Temp.: −20°C
• Solubility: H2O: 5 mg/mL, clear to faintly turbid, colorless to faintly
• Water Solubility: H2O: 5 mg/mL, clear to faintly turbid, colorless to faintly yellow
• CAS DataBase Reference: ALPHA2-MACROGLOBULIN(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA2-MACROGLOBULIN(95568-41-5)
• EPA Substance Registry System: ALPHA2-MACROGLOBULIN(95568-41-5)

Safety Data

• Hazard Codes: B
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 95568-41-5(Hazardous Substances Data)

Usage

Description

ALPHA2-MACROGLOBULIN, also known as α2-macroglobulin, is a high molecular weight glycoprotein found in blood plasma and other body fluids. It functions as a broad-spectrum protease inhibitor, capable of binding to and inactivating a wide range of proteolytic enzymes. This property makes it an essential component of the body's defense mechanism against proteolytic damage and inflammation.
Source:
ALPHA2-MACROGLOBULIN is synthesized primarily by the liver and secreted into the bloodstream, where it plays a crucial role in maintaining protease-antiprotease balance.
Production Methods:
The synthesis of ALPHA2-MACROGLOBULIN involves the assembly of its subunits, glycosylation, and the formation of disulfide bonds. The mature protein is then secreted into the bloodstream, where it carries out its functions.

Uses

Used in Medical Research:
ALPHA2-MACROGLOBULIN is used as a research tool for studying impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β, which serves as an early biomarker for mild cognitive impairment preceding Alzheimer's disease. This application aids in understanding the underlying mechanisms of neurodegenerative disorders and the development of potential therapeutic interventions.
Used in Complement System Regulation:
In the field of immunology, ALPHA2-MACROGLOBULIN is employed as a regulator of the classical and the MBL (mannose-binding lectin) pathway of complement activation. Its ability to control complement activation helps maintain the balance between immune response and preventing excessive inflammation, which is crucial for maintaining overall health.

Biochem/physiol Actions

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.