956011-64-6

Basic information

• Product Name: N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-ylacetamide
• Synonyms: N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-ylacetamide
• CAS NO: 956011-64-6
• Molecular Weight: 264.324
• Mol File: 956011-64-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-ylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-ylacetamide(956011-64-6)
• EPA Substance Registry System: N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-ylacetamide(956011-64-6)

Safety Data

• Hazardous Substances Data: 956011-64-6(Hazardous Substances Data)

Upstream product

• 576-26-1 2.6-dimethylphenol 
• 15980-22-0 3,5-dimethyl-4-hydroxyaniline 
• 2423-71-4 2,6-dimethyl-4-nitro phenol 
• 89531-58-8 N-(carboxymethyl)morpholine hydrochloride 

Downstream Products

• 956011-65-7 N-(4-hydroxy-3,5-dimethylphenyl)-2-morpholin-4-yl acetamide hydrochloride 
• 1408237-70-6 4-{2-[(4-hydroxy-3,5-dimethylphenyl)amino]-2-oxoethyl}-4-methylmorpholin-4-ium iodide 

Relevant articles and documents

DPPH radical scavenging activity of paracetamol analogues

Biochemical studies suggest a direct relationship between the radical scavenging activity of paracetamol (I) and its antipyretic and analgesic action. To evaluate the effect of chemical modifications on the radical scavenging activity of compounds of type I, analogues 1-14 were prepared and submitted to a stable free radical (DPPH; 1,1-diphenyl-2-picryl-hydrazyl) assay. All paracetamol derivatives showed a significant higher efficiency than the parent compound. This study showed that radical scavenging activity can be increased by decreasing the phenolic ortho substituents steric hindrance or by introducing substituents on the acyl moiety like an indazole ring or the ionic N-methyl morpholinium group. A significant activating effect was also observed by replacing the 1,4-acylamidophenol with a 1,4-acylamidonaphthol system.

4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A 4-amino-2, 6-dimethylphenol compound having the formula given in the description, acid-addition salts thereof, a process for preparing them, pharmaceutical composition comprising them and its use as anti-pyretic and anti-nociceptive agents.