957054-50-1

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-
• Synonyms: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine methanesulfonate;Thieno[3,2-d]pyriMidine, 2-(1H-indazol-4-yl)-6-[[4-(Methylsulfonyl)-1-piperazinyl]Methyl]-4-(4-Morpholinyl)- ,Mono MeSO3H salt
• CAS NO: 957054-50-1
• Molecular Formula: C23H27N7O3S2.CH4O3S
• Molecular Weight: 513.63558
• Mol File: 957054-50-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-(957054-50-1)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-(957054-50-1)

Safety Data

• Hazardous Substances Data: 957054-50-1(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- is a complex chemical compound that contains a thieno[3,2-d]pyrimidine core structure, as well as indazole, piperazine, and morpholine functional groups. The compound also features a methylsulfonyl group, which is a sulfur-containing organic functional group. This chemical may have potential applications in pharmaceutical research and drug development due to its unique structural features, which could contribute to its biological activity and pharmacological properties. Further studies and analysis are needed to fully understand the chemical characteristics and potential uses of this compound.

Upstream product

• 75-75-2 methanesulfonic acid 
• 957054-30-7 pictilisib 
• 186407-74-9 4-bromoindazole 
• 885675-66-1 4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine 
• 1416327-31-5 2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-ylboronic acid 
• 1146955-36-3 4-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-2-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 
• 16234-15-4 2-chloro-4-morpholinothieno[3,2-d]pyrimidine 
• 55289-36-6 3-bromo-2-methylaniline 
• 885618-31-5 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde 
• 1416327-30-4 1-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzotriazole 

Relevant articles and documents

A practical synthesis of a PI3K inhibitor under noncryogenic conditions via functionalization of a lithium triarylmagnesiate intermediate

We report a practical synthesis of PI3K inhibitor GDC-0941. The synthesis was achieved using a convergent approach starting from a thienopyrimidine intermediate through a sequence of formylation and reductive amination followed by Suzuki-Miyaura cross-coupling. Metalation of the thienopyrimidine intermediate involving the intermediacy of triarylmagnesiates allowed formylation under noncryogenic conditions to produce the corresponding aldehyde. We also investigated aminoalkylation via a benzotriazolyl-piperazine substrate as an alternative to the reductive amination route. We evaluated both palladium and nickel catalyzed processes for the borylation and Suzuki-Miyaura cross-coupling. Final deprotection and salt formation afforded the API.