959992-62-2

Basic information

• Product Name: 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
• Synonyms: 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
• CAS NO: 959992-62-2
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.06
• Mol File: 959992-62-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE(959992-62-2)
• EPA Substance Registry System: 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE(959992-62-2)

Safety Data

• Hazardous Substances Data: 959992-62-2(Hazardous Substances Data)

Usage

Description

6-Bromo-3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazine is a chemical compound that serves as a starting material and useful building block for the synthesis of various pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
6-Bromo-3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazine is used as a starting material and building block for the development of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the synthesis of new drugs, potentially leading to the discovery of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 959992-61-1 6-bromo-3-(2-bromoethoxy)-2-nitropyridine 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 443956-08-9 6-bromo-2-nitropyridin-3-ol 
• 1303588-62-6 C₇H₈Br₂N₂O 
• 443956-09-0 ethyl 2-(6-bromo-2-nitropyridin-3-yloxy)acetate 
• 337463-88-4 6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 

Downstream Products

• 1303587-79-2 6-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 
• 1303587-91-8 (2-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methanone 
• 1303582-20-8 (2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt 
• 1303583-13-2 pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate 
• 1303581-80-7 N-(thiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide 
• 1214927-90-8 C₁₄H₁₂BrN₃O₂ 
• 1214928-52-5 C₂₀H₁₈N₄O₂ 
• 1214926-61-0 C₁₆H₁₅N₃O₄ 
• 1214926-59-6 C₁₅H₁₃N₃O₄ 
• 1214928-02-5 C₂₄H₂₂N₄O₅ 
• 1214928-16-1 C₂₂H₁₈N₄O₅ 
• 20348-23-6 3,4-dihydro-2H-pyrido[3,2-b ][1,4]oxazine 
• 959992-64-4 tert-butyl 6-bromo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-carboxylate 

Relevant articles and documents

Macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one and pharmaceutical composition and application thereof

The present invention relates to a macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one as shown in the formula (I) and/or a pharmaceutically acceptable salt thereof, and a composition of a compound of the formula (I) and/or a pharmaceutically acceptable salt thereof, a preparation method thereof, application thereof as a Wee1 inhibitor and application thereof as a sensitizer for cancer chemotherapy or radiotherapy. The macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one can effectively inhibit Wee1 and related signaling pathways, and has good cancer treatment and/or relieving effect.The formula is shown in the description.

RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY

The present invention provides compounds or a pharmaceutically acceptable salt thereof which inhibit the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and are therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused morpholine compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS

The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins.