96026-63-0

Basic information

• Product Name: Uridine, 5'-(4-oxopentanoate)
• CAS NO: 96026-63-0
• Molecular Formula: C14H18N2O8
• Molecular Weight: 342.306
• Mol File: 96026-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-(4-oxopentanoate)(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-(4-oxopentanoate)(96026-63-0)
• EPA Substance Registry System: Uridine, 5'-(4-oxopentanoate)(96026-63-0)

Safety Data

• Hazardous Substances Data: 96026-63-0(Hazardous Substances Data)

Upstream product

• 58-96-8 β-D/L-uridine 
• 647834-80-8 O-levulinyl acetonoxime 

Downstream Products

• 1455429-80-7 5'-O-levulinyl 2'-O-monomethoxytrityl 3'-O-phosphoramidous ribouridine 
• 1455429-77-2 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine 
• 1455429-79-4 5'-O-levulinyl 3'-O-monomethoxytrityl ribouridine 
• 96026-65-2 Benzoic acid (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-(4-oxo-pentanoyloxymethyl)-tetrahydro-furan-3-yl ester 
• 96026-64-1 Benzoic acid (2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-(4-oxo-pentanoyloxymethyl)-tetrahydro-furan-3-yl ester 
• 96026-66-3 4-Oxo-pentanoic acid (2R,3S,4R,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester 
• 96041-76-8 4-Oxo-pentanoic acid (2R,3R,4R,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Enzymatic parallel kinetic resolution of mixtures of d / l 2′-deoxy and ribonucleosides: An approach for the isolation of β- L -nucleosides

We have developed a lipase-catalyzed parallel kinetic resolution of mixtures of β-d/l-nucleosides. The opposite selectivity during acylation exhibited by Pseudomonas cepacia lipase (PSL-C) with β-d- and β-l-nucleosides furnished acylated compounds that have different R f values. As a consequence, isolation of both products was achieved by simple column chromatography. Computer modeling of the transition-state analogues during acylation of β-d- and β-l-2′-deoxycytidine with PSL-C was carried out to explain the high selectivity. PSL-C favored the 3′-O-levulination of the β-d enantiomer, whereas the 5′-OH group was acylated in 2′-deoxy-β-l-cytidine. In both cases, the cytosine base was placed in the alternate hydrophobic pocket of PSLs substrate-binding site, where it can form extra hydrogen bonds (in addition to the five essential catalytically relevant hydrogen bonds) that stabilize these intermediates catalyzing the selective acylation of β-d/l-nucleosides.