96056-64-3

Basic information

• Product Name: METHYL 2-INDOLINECARBOXYLATE
• Synonyms: METHYL 2-INDOLINECARBOXYLATE;2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER;(S)-indoline-2-carboxylic acid methyl ester hydrochloride;1H-Indole-2-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride (1:1), (2S)-;(S)-Methyl indoline-2-carboxylate hydrochloride
• CAS NO: 96056-64-3
• Molecular Formula: C₁₀H₁₁NO₂*ClH
• Molecular Weight: 177.2
• EINECS: 1592732-453-0
• Mol File: 96056-64-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 117℃
• Boiling Point: 380°C at 760 mmHg
• Flash Point: 183.6°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 1.88E-06mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: METHYL 2-INDOLINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-INDOLINECARBOXYLATE(96056-64-3)
• EPA Substance Registry System: METHYL 2-INDOLINECARBOXYLATE(96056-64-3)

Safety Data

• Hazard Codes: Xn
• Statements: 43-48/22-62
• Safety Statements: 22-25-26-36/37
• Hazardous Substances Data: 96056-64-3(Hazardous Substances Data)

Usage

Description

METHYL 2-INDOLINECARBOXYLATE, with the molecular formula C11H11NO2, is an organic compound belonging to the class of indolecarboxylic acids and derivatives. METHYL 2-INDOLINECARBOXYLATE features an indole ring with a carboxylic acid group attached, known for its pleasant aroma and potential pharmacological properties.
Used in Pharmaceutical Industry:
METHYL 2-INDOLINECARBOXYLATE is used as an intermediate in the manufacturing of pharmaceuticals for its role in the synthesis of various medicinal compounds.
Used in Perfume Industry:
METHYL 2-INDOLINECARBOXYLATE is used as a fragrance ingredient in perfumes and other scented products due to its pleasant smell.
Used in Organic Synthesis:
METHYL 2-INDOLINECARBOXYLATE is used as a precursor in organic synthesis for the production of a range of fine chemicals.
Used in Research and Development:
METHYL 2-INDOLINECARBOXYLATE is used in research for its potential anti-inflammatory and antioxidant effects, exploring its applications in therapeutic areas.

InChI:InChI=1/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/t8-/m1/s1

Upstream product

• 67-56-1 methanol 
• 16851-56-2 indolin-2-yl carboxylic acid 

Downstream Products

• 139456-30-7 4-Acetyl-2-(4-chloro-phenyl)-10,10a-dihydro-2H-[1,2,4]triazino[4,5-a]indol-1-one 
• 139456-29-4 4-Acetyl-2-(4-fluoro-phenyl)-10,10a-dihydro-2H-[1,2,4]triazino[4,5-a]indol-1-one 
• 139456-28-3 4-Acetyl-2-phenyl-10,10a-dihydro-2H-[1,2,4]triazino[4,5-a]indol-1-one 
• 110659-07-9 N-acetyl-indoline-2-carboxylic acid methyl ester 
• 110592-39-7 (S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester 
• 59040-84-5 indoline-2-carboxylic acid methyl ester 

Relevant articles and documents

Catalytic asymmetric hydrogenation of indoles using a rhodium complex with a chiral bisphosphine ligand PhTRAP

Highly enantioselective hydrogenation of N-protected indoles was successfully developed by use of the rhodium catalyst generated in situ from [Rh(nbd)2]SbF6 and the chiral bisphosphine PhTRAP, which can form a trans-chelate complex with a transition metal atom. The PhTRAP-rhodium catalyst required a base (e.g., Cs2CO3) for the achievement of high enantioselectivity. Various 2-substituted N-acetylindoles were converted into the corresponding chiral indolines with up to 95% ee. The hydrogenations of 3-substituted N-tosylindoles yielded indolines possessing a stereogenic center at the 3-position with high enantiomeric excesses (up to 98% ee).

Catalytic asymmetric hydrogenation of heteroaromatic compounds, indoles [12]

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