96057-59-9

Basic information

• Product Name: ethyl 3-oxo-3-(quinolin-2-yl)propanoate
• Synonyms: ethyl 3-oxo-3-(quinolin-2-yl)propanoate
• CAS NO: 96057-59-9
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.25792
• Mol File: 96057-59-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 3-oxo-3-(quinolin-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-oxo-3-(quinolin-2-yl)propanoate(96057-59-9)
• EPA Substance Registry System: ethyl 3-oxo-3-(quinolin-2-yl)propanoate(96057-59-9)

Safety Data

• Hazardous Substances Data: 96057-59-9(Hazardous Substances Data)

Upstream product

• 4491-33-2 ethyl quinoline-2-carboxylate 
• 141-78-6 ethyl acetate 
• 19575-07-6 quinoline-2-carboxylic acid methyl ester 
• 93-10-7 quinoline-2-carboxylic acid 
• 6148-64-7 ethyl potassium malonate 
• 1011-47-8 1-quinolin-2-yl-ethanone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 64232-02-6 ethyl ester of 1-(2-quinolyl)-3-phenyl-3,4-dihydrobenzoquinoline-2-carboxylic acid 
• 164359-12-0 ethyl 3-(p-bromophenyl)-3-(2-naphthylamino)-2-(quinoline-2-carbonyl)propanoate 
• 164359-13-1 ethyl 3-(p-methoxyphenyl)-3-(2-naphthylamino)-2-(quinoline-2-carbonyl)propanoate 
• 1011-47-8 1-quinolin-2-yl-ethanone 
• 154308-08-4 ethyl 3-benzylamino-3-(2-quinolinyl)propionate 
• 154308-09-5 ethyl 3-(4-methoxybenzyl)amino-3-(2-quinolinyl)propionate 
• 154308-33-5 7-benzyl-6-(2-quinolinyl)-1H-pyrido<3,4-c>pyridine-3,8(4H,7H)-dione 
• 154308-24-4 ethyl 1-benzyl-1,2-dihydro-4-hydroxy-2-oxo-6-(2-quinolinyl)pyridine-3-carboxylate 
• 154308-21-1 ethyl 1-benzyl-4-hydroxy-2-oxo-6-(2-quinolinyl)-1,2,5,6-tetrahydropyridine-3-carboxylate 
• 154308-27-7 ethyl 1-benzyl-1,2-dihydro-4-methoxy-2-oxo-6-(2-quinolinyl)pyridine-3-carboxylate 

Relevant articles and documents

Compound, luminescent layer guest material, organic electroluminescent device and display device

The invention provides a compound as shown in a general formula (I). The compoundcan be used for an organic electroluminescent device as a guest material of a luminescent layer. The compound comprises a natural heterocyclic ring and iridium (Ir) coordinated structure, and the light emitting wavelength of the compound can be effectively regulated and controlled. When the compound is used as a guest material of a light-emitting layer, the light-emitting efficiency and the light stability of the organic electroluminescent device can be improved. In addition, the compound provided by the invention is small in molecular weight, is applied to a light-emitting layer, is relatively low in evaporation temperature, and is beneficial to processing. The invention also provides a luminescent layer guest material containing the compound shown in the general formula (I), an organic electroluminescent device and a display device.

Fragment-based discovery of pyrimido[1,2-B]indazole PDE10A inhibitors

In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug discovery (FBDD). The pyrazolopyridine derivative 2 was found to be a fragment hit compound which could occupy a part of the binding site of PDE10A enzyme by using the method of the X-ray co-crystal structure analysis. On the basis of the crystal structure of compound 2 and PDE10A protein, a number of compounds were synthesized and evaluated, by means of structure-activity relationship (SAR) studies, which culminated in the discovery of a novel pyrimidoindazole derivative 13 having good physicochemical properties.

Total synthesis of streptonigrone

(Chemical Equation Presented) A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad-Limpach reaction, rather than the customary Friedlaender methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.