961-82-0

Basic information

• Product Name: 7-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine
• Synonyms: 7-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine
• CAS NO: 961-82-0
• Molecular Weight: 253.26
• Mol File: 961-82-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 7-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine(961-82-0)
• EPA Substance Registry System: 7-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine(961-82-0)

Safety Data

• Hazardous Substances Data: 961-82-0(Hazardous Substances Data)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 99-81-0 4-Nitrophenacyl bromide 
• 10342-64-0 p-nitroacetophenone oxime 
• 100-19-6 (4-nitrophenyl)ethanone 
• 296788-00-6 1-(4-nitrophenyl)ethanone O-acetyl oxime 

Downstream Products

• 64730-34-3 7-methyl-2-(4-aminophenyl)imidazo-[1,2-a]pyridine 
• 93764-91-1 7-methyl-2-(4-nitrophenyl)-3-nitrosoimidazo[1,2-a]pyridine 
• 103779-34-6 N-[4-(7-Methyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-acetamide 

Relevant articles and documents

Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry

The present work describes the solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to

Novel one step synthesis of imidazo[1,2-a]pyridines and Zolimidine via iron/iodine-catalyzed Ortoleva-King type protocol

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3·6H2O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine.

Copper catalyzed tandem oxidative C-H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines

A simple and convenient strategy is described for the synthesis of imidazo[1,2-a]pyridines via inexpensive copper-catalyzed tandem imine formation and intramolecular aerobic oxidative C-H bond amination/cyclizations. An array of imidazo[1,2-a]pyridines were prepared by the reaction of readily available acetophenones and 2-aminopyridines in good to excellent yields (48-92%). The scope of the method was validated by a single step synthesis of Zolimidine, a drug used for peptic ulcers, in 61% yield. The Royal Society of Chemistry 2013.