96166-00-6

Basic information

• Product Name: 5-(benzyloxy)pyridin-2-amine
• Synonyms: 5-(benzyloxy)pyridin-2-amine;5-Benzyloxypyridin-2-ylamine;2-PyridinaMine, 5-(phenylMethoxy)-;5-(Phenylmethoxy)-2-pyridinamine
• CAS NO: 96166-00-6
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol File: 96166-00-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 374.496°C at 760 mmHg
• Flash Point: 180.289°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: 5-(benzyloxy)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)pyridin-2-amine(96166-00-6)
• EPA Substance Registry System: 5-(benzyloxy)pyridin-2-amine(96166-00-6)

Safety Data

• Hazardous Substances Data: 96166-00-6(Hazardous Substances Data)

Usage

General Description

5-(benzyloxy)pyridin-2-amine is a chemical compound with the molecular formula C13H12N2O. It is a derivative of pyridine and contains a benzyl ether group attached to the fifth carbon atom and an amine group attached to the second carbon atom. 5-(benzyloxy)pyridin-2-amine is commonly used in organic synthesis and medicinal chemistry research due to its potential pharmacological properties. It has been studied for its potential applications in the development of new drugs and pharmaceuticals. Additionally, it may also be used as a building block in the synthesis of various organic compounds.

InChI:InChI=1/C12H12N2O/c13-12-7-6-11(8-14-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,13,14)

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 100-51-6 benzyl alcohol 
• 1083329-33-2 2-N-(2,5-dimethylpyrrolo)-5-benzyloxypyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 1267854-62-5 2-triphenylmethylamino-5-bromopyridine 

Downstream Products

• 96165-99-0 C₄₉H₅₅N₃O₁₂ 
• 630120-99-9 5-(benzyloxy)-2-bromopyridine 
• 1204413-49-9 2-acetamido-5-benzyloxypyridine 
• 1578264-27-3 C₁₇H₂₀N₂O₃ 
• 1578264-29-5 C₁₈H₂₂N₂O₃ 
• 1578264-37-5 C₁₉H₁₈N₄O₄ 
• 941596-78-7 5-(benzyloxy)-3-bromopyridin-2-amine 
• 1431534-08-5 N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide 
• 1431534-09-6 6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[4,5-b]pyridine 
• 55717-46-9 6-aminopyridin-3-ol 

Relevant articles and documents

AZOLE-SUBSTITUTED PYRIDINE COMPOUND

The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.