96187-53-0Relevant articles and documents
Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition
Madak, Joseph T.,Cuthbertson, Christine R.,Chen, Wenmin,Showalter, Hollis D.,Neamati, Nouri
, p. 13875 - 13878 (2017/09/18)
Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To further understand brequinar-based DHODH inhibition and DHODH′s therapeutic relevance in cancer, we
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
Sykes, David B.,Kfoury, Youmna S.,Mercier, Fran?ois E.,Wawer, Mathias J.,Law, Jason M.,Haynes, Mark K.,Lewis, Timothy A.,Schajnovitz, Amir,Jain, Esha,Lee, Dongjun,Meyer, Hanna,Pierce, Kerry A.,Tolliday, Nicola J.,Waller, Anna,Ferrara, Steven J.,Eheim, Ashley L.,Stoeckigt, Detlef,Maxcy, Katrina L.,Cobert, Julien M.,Bachand, Jacqueline,Szekely, Brian A.,Mukherjee, Siddhartha,Sklar, Larry A.,Kotz, Joanne D.,Clish, Clary B.,Sadreyev, Ruslan I.,Clemons, Paul A.,Janzer, Andreas,Schreiber, Stuart L.,Scadden, David T.
, p. 171 - 15,186 (2016/09/28)
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a power
4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases
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, (2008/06/13)
Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful for the treatment of skin and muco-epithelial diseases.
